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Materials 2015, 8(7), 3815-3830; doi:10.3390/ma8073815

Nanosized Hydroxyapatite Coating on PEEK Implants Enhances Early Bone Formation: A Histological and Three-Dimensional Investigation in Rabbit Bone

1
Department of Prostodontics, Faculty of Odontology, Malmö University, Malmö S-214 21, Sweden
2
Department of Radiopraxis Science, Kanagawa Dental University, Yokosuka, Kanagawa Prefecture 238-8580, Japan
3
Promimic AB, Stena Center 1B, Göteborg S-412 92, Sweden
*
Author to whom correspondence should be addressed.
Academic Editor: Andrew J. Ruys
Received: 24 March 2015 / Revised: 4 June 2015 / Accepted: 17 June 2015 / Published: 25 June 2015
(This article belongs to the Special Issue Bioceramics)
View Full-Text   |   Download PDF [1582 KB, uploaded 25 June 2015]   |  

Abstract

Polyether ether ketone (PEEK) has been frequently used in spinal surgery with good clinical results. The material has a low elastic modulus and is radiolucent. However, in oral implantology PEEK has displayed inferior ability to osseointegrate compared to titanium materials. One idea to reinforce PEEK would be to coat it with hydroxyapatite (HA), a ceramic material of good biocompatibility. In the present study we analyzed HA-coated PEEK tibial implants via histology and radiography when following up at 3 and 12 weeks. Of the 48 implants, 24 were HA-coated PEEK screws (test) and another 24 implants served as uncoated PEEK controls. HA-coated PEEK implants were always osseointegrated. The total bone area (BA) was higher for test compared to control implants at 3 (p < 0.05) and 12 weeks (p < 0.05). Mean bone implant contact (BIC) percentage was significantly higher (p = 0.024) for the test compared to control implants at 3 weeks and higher without statistical significance at 12 weeks. The effect of HA-coating was concluded to be significant with respect to early bone formation, and HA-coated PEEK implants may represent a good material to serve as bone anchored clinical devices. View Full-Text
Keywords: polyether ether ketone; HA; biomaterial; histology polyether ether ketone; HA; biomaterial; histology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Johansson, P.; Jimbo, R.; Kozai, Y.; Sakurai, T.; Kjellin, P.; Currie, F.; Wennerberg, A. Nanosized Hydroxyapatite Coating on PEEK Implants Enhances Early Bone Formation: A Histological and Three-Dimensional Investigation in Rabbit Bone. Materials 2015, 8, 3815-3830.

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