Next Article in Journal
Revisiting the Hydrogen Storage Behavior of the Na-O-H System
Next Article in Special Issue
Process Optimisation to Control the Physico-Chemical Characteristics of Biomimetic Nanoscale Hydroxyapatites Prepared Using Wet Chemical Precipitation
Previous Article in Journal
Development of Self-Consolidating High Strength Concrete Incorporating Treated Palm Oil Fuel Ash
Previous Article in Special Issue
Microstructure Evolution and Mechanical Properties Improvement in Liquid-Phase-Sintered Hydroxyapatite by Laser Sintering
Article Menu

Export Article

Open AccessArticle
Materials 2015, 8(5), 2174-2190; doi:10.3390/ma8052174

Medium-Term Function of a 3D Printed TCP/HA Structure as a New Osteoconductive Scaffold for Vertical Bone Augmentation: A Simulation by BMP-2 Activation

1
Division of Fixed Prosthodontics and Biomaterials, University of Geneva, University Clinics of Dental Medicine, 19, rue Barthélemy-Menn, Geneva 1205, Switzerland
2
Department of Maxillofacial and Oral Surgery, Division of Oral and Maxillofacial Pathology (HUG), University Clinics of Dental Medicine, 19, rue Barthélemy-Menn, Geneva 1205, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editor: Naozumi Teramoto
Received: 2 March 2015 / Revised: 30 March 2015 / Accepted: 20 April 2015 / Published: 28 April 2015
(This article belongs to the Special Issue Bioceramics)
View Full-Text   |   Download PDF [1238 KB, uploaded 8 May 2015]   |  

Abstract

Introduction: A 3D-printed construct made of orthogonally layered strands of tricalcium phosphate (TCP) and hydroxyapatite has recently become available. The material provides excellent osteoconductivity. We simulated a medium-term experiment in a sheep calvarial model by priming the blocks with BMP-2. Vertical bone growth/maturation and material resorption were evaluated. Materials and methods: Titanium hemispherical caps were filled with either bare- or BMP-2 primed constructs and placed onto the calvaria of adult sheep (n = 8). Histomorphometry was performed after 8 and 16 weeks. Results: After 8 weeks, relative to bare constructs, BMP-2 stimulation led to a two-fold increase in bone volume (Bare: 22% ± 2.1%; BMP-2 primed: 50% ± 3%) and a 3-fold decrease in substitute volume (Bare: 47% ± 5%; BMP-2 primed: 18% ± 2%). These rates were still observed at 16 weeks. The new bone grew and matured to a haversian-like structure while the substitute material resorbed via cell- and chemical-mediation. Conclusion: By priming the 3D construct with BMP-2, bone metabolism was physiologically accelerated, that is, enhancing vertical bone growth and maturation as well as material bioresorption. The scaffolding function of the block was maintained, leaving time for the bone to grow and mature to a haversian-like structure. In parallel, the material resorbed via cell-mediated and chemical processes. These promising results must be confirmed in clinical tests. View Full-Text
Keywords: bone substitute block; 3D-printing; BMP-2; animal experiments; guided tissue regeneration; bone regeneration bone substitute block; 3D-printing; BMP-2; animal experiments; guided tissue regeneration; bone regeneration
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Moussa, M.; Carrel, J.-P.; Scherrer, S.; Cattani-Lorente, M.; Wiskott, A.; Durual, S. Medium-Term Function of a 3D Printed TCP/HA Structure as a New Osteoconductive Scaffold for Vertical Bone Augmentation: A Simulation by BMP-2 Activation. Materials 2015, 8, 2174-2190.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top