Nanocomposites for Biomedical Engineering Applications

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 4767

Special Issue Editor


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Guest Editor
Director of Biomedical Engineering, University of Sydney, Sydney, NSW, Australia
Interests: biomaterials; bioceramics; ceramics; hydroxyapatite; alumina; ZTA (zirconia toughened alumina); DLC (diamond-like carbon); fibre-reinforced ceramics; porous materials; scaffolds; tissue engineering; bioactive glasses; electrophoretic deposition; bionic feedthroughs; bioactive coatings; DLC coatings; drug delivery
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Special Issue Information

Dear Colleagues,

Nanocomposites Defined

A nanocomposite is a special class of composite materials in which the reinforcement phase is in the 1 to 100nm dimensional scale, giving nanostructure to the composite. As with any composite, the matrix and reinforcement phases can each be one of either metal, ceramic, or polymer. The reinforcement phase can come in various forms, such as nanospheres, equiaxed nanoparticles, acicular nanoparticles, platy nanoparticles, and nanofibers, to name but a few examples. A common example is metal nanoparticles in a ceramic matrix. The field of biomimetics reveals a number of successful nanocomposites, for example, bone calcium phosphate nano-platelets embedded epitaxially in a matrix of collagen nanofibrils, with the composite manifesting a complex hierarchical nanostructure and microstructure. The mechanical benefits of the nanocomposite approach are clear in the case of bone. Bone is orders of magnitude harder than collagen, and orders of magnitude tougher than polycrystalline calcium phosphate ceramic. The nanocomposite approach is commonly used for mechanical enhancement. However, the nanocomposite approach can also be used for other purposes—for example, photonics (optical arrays of diffracting nanoparticles in a transparent matrix), which can have biomedical application in sensors, and superparamagnetism (magnetic nanoparticles in a matrix), which can have biomedical applications in hyperthermic–heating implants.  

Scope of the Special Issue: Nanocomposites for Biomedical Engineering Applications

This special issue invites manuscripts on Nanocomposites for Biomedical Engineering Applications. As the above introduction makes clear, the scope is broad. Solid composite materials involving a reinforcement phase in the 1 to 100 nm range in a matrix, with a biomedical engineering application, are of interest. The nanocomposite approach need not be purely used for mechanical enhancement. However, the nanocomposite needs to have a biomedical application. Therefore, if implantable, it needs to be fabricated from biocompatible components. If for external use, the biomedical engineering purpose needs to be explicit. Biomimetic submissions are also welcome.

Prof. Dr. Andrew Ruys
Guest Editor

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Keywords

  • nanocomposites
  • biomaterials
  • biomedical engineering
  • composite materials
  • biomimetics
  • nanoparticle
  • nanostructure

Published Papers (2 papers)

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Research

17 pages, 2502 KiB  
Article
Performance of Graphene/Polydimethylsiloxane Surfaces against S. aureus and P. aeruginosa Single- and Dual-Species Biofilms
by Isabel M. Oliveira, Marisa Gomes, Luciana C. Gomes, Manuel F. R. Pereira, Olívia S. G. P. Soares and Filipe J. Mergulhão
Nanomaterials 2022, 12(3), 355; https://doi.org/10.3390/nano12030355 - 22 Jan 2022
Cited by 7 | Viewed by 3108
Abstract
The increasing incidence of implant-associated infections has prompted the development of effective strategies to prevent biofilm formation on these devices. In this work, pristine graphene nanoplatelet/polydimethylsiloxane (GNP/PDMS) surfaces containing different GNP loadings (1, 2, 3, 4, and 5 wt%) were produced and evaluated [...] Read more.
The increasing incidence of implant-associated infections has prompted the development of effective strategies to prevent biofilm formation on these devices. In this work, pristine graphene nanoplatelet/polydimethylsiloxane (GNP/PDMS) surfaces containing different GNP loadings (1, 2, 3, 4, and 5 wt%) were produced and evaluated on their ability to mitigate biofilm development. After GNP loading optimization, the most promising surface was tested against single- and dual-species biofilms of Staphylococcus aureus and Pseudomonas aeruginosa. The antibiofilm activity of GNP/PDMS surfaces was determined by the quantification of total, viable, culturable, and viable but nonculturable (VBNC) cells, as well as by confocal laser scanning microscopy (CLSM). Results showed that 5 wt% GNP loading reduced the number of total (57%), viable (69%), culturable (55%), and VBNC cells (85%) of S. aureus biofilms compared to PDMS. A decrease of 25% in total cells and about 52% in viable, culturable, and VBNC cells was observed for P. aeruginosa biofilms. Dual-species biofilms demonstrated higher resistance to the antimicrobial activity of GNP surfaces, with lower biofilm cell reductions (of up to 29% when compared to single-species biofilms). Still, the effectiveness of these surfaces in suppressing single- and dual-species biofilm formation was confirmed by CLSM analysis, where a decrease in biofilm biovolume (83% for S. aureus biofilms and 42% for P. aeruginosa and dual-species biofilms) and thickness (on average 72%) was obtained. Overall, these results showed that pristine GNPs dispersed into the PDMS matrix were able to inhibit biofilm growth, being a starting point for the fabrication of novel surface coatings based on functionalized GNP/PDMS composites. Full article
(This article belongs to the Special Issue Nanocomposites for Biomedical Engineering Applications)
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18 pages, 20309 KiB  
Article
Biogenic Ferrihydrite Nanoparticles Produced by Klebsiella oxytoca: Characterization, Physicochemical Properties and Bovine Serum Albumin Interactions
by Nicoleta Cazacu, Claudia G. Chilom, Sorina Iftimie, Maria Bălășoiu, Valentina P. Ladygina, Sergey V. Stolyar, Oleg L. Orelovich, Yuriy S. Kovalev and Andrey V. Rogachev
Nanomaterials 2022, 12(2), 249; https://doi.org/10.3390/nano12020249 - 13 Jan 2022
Cited by 6 | Viewed by 1911
Abstract
The synthesis of nanoparticles inside microorganisms is an economical alternative to chemical and physical methods of nanoparticle synthesis. In this study, ferrihydrite nanoparticles synthesized by Klebsiella oxytoca bacterium in special conditions were characterized by scanning electron microscopy (SEM), energy-dispersive X-ray analysis (EDS), small-angle [...] Read more.
The synthesis of nanoparticles inside microorganisms is an economical alternative to chemical and physical methods of nanoparticle synthesis. In this study, ferrihydrite nanoparticles synthesized by Klebsiella oxytoca bacterium in special conditions were characterized by scanning electron microscopy (SEM), energy-dispersive X-ray analysis (EDS), small-angle X-ray (SAXS), UV-Vis spectroscopy, fluorescence, fluorescence resonance energy transfer (FRET), and molecular docking. The morphology and the structure of the particles were characterized by means of SEM and SAXS. The elemental content was determined by means of the EDS method. The absorption properties of the ferrihydrite nanoparticles were investigated by UV-Vis spectroscopy. The binding mechanism of the biogenic ferrihydrite nanoparticles to Bovine Serum Albumin (BSA) protein, studied by fluorescence, showed a static and weak process, combined with FRET. Protein denaturation by temperature and urea in the presence of the ferrihydrite nanoparticles demonstrated their influence on the unfolding process. The AutoDock Vina and UCSF Chimera programs were used to predict the optimal binding site of the ferrihydrite to BSA and to find the location of the hydrophobic cavities in the sub-domain IIA of the BSA structure. Full article
(This article belongs to the Special Issue Nanocomposites for Biomedical Engineering Applications)
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