Special Issue "Deep-Sea Natural Products"
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (28 February 2013)
Dr. Danielle Skropeta
School of Chemistry, University of Wollongong, Wollongong NSW 2522, Australia
Phone: +61 2 4221 4360
Fax: +61 2 4221 4287
Oceans cover 70% of the world’s surface, with 95% greater than 1000 m deep. Yet of the 30,000 marine natural products reported, less than 2% derive from deep-sea organisms. Today, with improved acoustic technology and greater access to submersibles, deep-sea exploration is uncovering extensive deep-water reefs that are home to a myriad of new species, making the deep sea one of the most biodiverse habitats on the planet. In the search for sources of new chemical diversity, deep-sea natural products have emerged as a new frontier in drug discovery and development, with over 60% exhibiting significant bioactivity.
Life in the deep sea involves exposure to high hydrostatic pressures, variable temperatures and low oxygen and light, requiring its inhabitants to adapt their biochemical machinery to cope with the extreme conditions. This has the potential to affect both their primary and secondary metabolic pathways, giving rise to structurally unique metabolites.
The deep-sea is a vast and relatively untapped reservoir of unique molecular, structural and biological diversity. As the Guest Editor, I invite scientists to present their recent advances in the field of deep-sea natural products, that is marine natural products obtained from organisms collected at depths of greater than 50 m (164 feet), including the isolation and identification of both deep-sea microbial and invertebrate natural products; biological evaluation, synthesis and biosynthesis; and studies addressing issues challenging the field such as the culturing of deep-sea microbes and deep-sea sponges.
Dr. Danielle Skropeta
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed Open Access monthly journal published by MDPI.
- marine natural products
- bioactive compounds
- synthesis; deep-sea
- extreme environments
- manned submersibles
- remotely operated vehicles
Article: Deep Sea Water Modulates Blood Pressure and Exhibits Hypolipidemic Effects via the AMPK-ACC Pathway: An in Vivo Study
Mar. Drugs 2013, 11(6), 2183-2202; doi:10.3390/md11062183
Received: 12 April 2013; in revised form: 14 May 2013 / Accepted: 22 May 2013 / Published: 17 June 2013| Cited by 1 | PDF Full-text (1372 KB) | HTML Full-text | XML Full-text
Article: Tetroazolemycins A and B, Two New Oxazole-Thiazole Siderophores from Deep-Sea Streptomyces olivaceus FXJ8.012
Mar. Drugs 2013, 11(5), 1524-1533; doi:10.3390/md11051524
Received: 16 February 2013; in revised form: 18 April 2013 / Accepted: 24 April 2013 / Published: 10 May 2013| PDF Full-text (747 KB) | HTML Full-text | XML Full-text | Supplementary Files
Article: Photoprotective Bioactivity Present in a Unique Marine Bacteria Collection from Portuguese Deep Sea Hydrothermal Vents
Mar. Drugs 2013, 11(5), 1506-1523; doi:10.3390/md11051506
Received: 13 March 2013; in revised form: 16 April 2013 / Accepted: 23 April 2013 / Published: 10 May 2013| Cited by 2 | PDF Full-text (876 KB) | HTML Full-text | XML Full-text | Supplementary Files
Article: Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
Mar. Drugs 2013, 11(4), 1399-1408; doi:10.3390/md11041399
Received: 28 January 2013; in revised form: 25 March 2013 / Accepted: 7 April 2013 / Published: 23 April 2013| Cited by 3 | PDF Full-text (944 KB) | HTML Full-text | XML Full-text | Supplementary Files
Mar. Drugs 2013, 11(4), 1126-1139; doi:10.3390/md11041126
Received: 21 February 2013; in revised form: 5 March 2013 / Accepted: 15 March 2013 / Published: 2 April 2013| Cited by 1 | PDF Full-text (430 KB) | HTML Full-text | XML Full-text | Supplementary Files
Review: The Deep-Sea Natural Products, Biogenic Polyphosphate (Bio-PolyP) and Biogenic Silica (Bio-Silica), as Biomimetic Scaffolds for Bone Tissue Engineering: Fabrication of a Morphogenetically-Active Polymer
Mar. Drugs 2013, 11(3), 718-746; doi:10.3390/md11030718
Received: 10 January 2013; in revised form: 4 February 2013 / Accepted: 6 February 2013 / Published: 8 March 2013| PDF Full-text (1910 KB) | HTML Full-text | XML Full-text
Communication: Isolation, Characterization, and Bioactivity Evaluation of 3-((6-Methylpyrazin-2-yl)methyl)-1H-indole, a New Alkaloid from a Deep-Sea-Derived Actinomycete Serinicoccus profundi sp. nov.
Mar. Drugs 2013, 11(1), 33-39; doi:10.3390/md11010033
Received: 15 October 2012; in revised form: 7 November 2012 / Accepted: 22 November 2012 / Published: 27 December 2012| Cited by 4 | PDF Full-text (325 KB) | HTML Full-text | XML Full-text | Supplementary Files
Article: Ammonificins C and D, Hydroxyethylamine Chromene Derivatives from a Cultured Marine Hydrothermal Vent Bacterium, Thermovibrio ammonificans
Mar. Drugs 2012, 10(10), 2300-2311; doi:10.3390/md10102300
Received: 30 July 2012; in revised form: 18 September 2012 / Accepted: 29 September 2012 / Published: 19 October 2012| Cited by 1 | PDF Full-text (431 KB) | HTML Full-text | XML Full-text
Article: Natural Products from Antarctic Colonial Ascidians of the Genera Aplidium and Synoicum: Variability and Defensive Role
Mar. Drugs 2012, 10(8), 1741-1764; doi:10.3390/md10081741
Received: 29 June 2012; in revised form: 1 August 2012 / Accepted: 8 August 2012 / Published: 20 August 2012| Cited by 4 | PDF Full-text (997 KB) | HTML Full-text | XML Full-text | Supplementary Files
Last update: 10 October 2012