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Photoprotective Bioactivity Present in a Unique Marine Bacteria Collection from Portuguese Deep Sea Hydrothermal Vents
BIOALVO, SA TEC LABS—Innovation Center, Campus of FCUL, Campo Grande, 1749-016 Lisbon, Portugal
University of Lisbon, Faculty of Sciences, Centre for Biodiversity, Functional and Integrative Genomics (BioFIG), Campus of FCUL, Campo Grande, 1749-016 Lisbon, Portugal
* Author to whom correspondence should be addressed.
Received: 13 March 2013; in revised form: 16 April 2013 / Accepted: 23 April 2013 / Published: 10 May 2013
Abstract: Interesting biological activities have been found for numerous marine compounds. In fact, screening of phylogenetically diverse marine microorganisms from extreme environments revealed to be a rational approach for the discovery of novel molecules with relevant bioactivities for industries such as pharmaceutical and cosmeceutical. Nevertheless, marine sources deliverables are still far from the expectations and new extreme sources of microbes should be explored. In this work, a marine prokaryotic collection from four Mid-Atlantic Ridge (MAR) deep sea hydrothermal vents near the Azores Islands, Portugal, was created, characterized and tested for its photoprotective capacity. Within 246 isolates, a polyphasic approach, using chemotaxonomic and molecular typing methods, identified 23-related clusters of phenetically similar isolates with high indexes of diversity. Interestingly, 16S rRNA gene sequencing suggested the presence of 43% new prokaryotic species. A sub-set of 139 isolates of the prokaryotic collection was selected for biotechnological exploitation with 484 bacterial extracts prepared in a sustainable upscalling manner. 22% of the extracts showed an industrially relevant photoprotective activity, with two extracts, belonging to new strains of the species Shewanella algae and Vibrio fluvialis, uniquely showing UV-A, UV-B and UV-C protective capacity. This clearly demonstrates the high potential of the bacteria MAR vents collection in natural product synthesis with market applications.
Keywords: deep sea; marine bacteria; natural products; MAR hydrothermal vents; photoprotection
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Martins, A.; Tenreiro, T.; Andrade, G.; Gadanho, M.; Chaves, S.; Abrantes, M.; Calado, P.; Tenreiro, R.; Vieira, H. Photoprotective Bioactivity Present in a Unique Marine Bacteria Collection from Portuguese Deep Sea Hydrothermal Vents. Mar. Drugs 2013, 11, 1506-1523.
Martins A, Tenreiro T, Andrade G, Gadanho M, Chaves S, Abrantes M, Calado P, Tenreiro R, Vieira H. Photoprotective Bioactivity Present in a Unique Marine Bacteria Collection from Portuguese Deep Sea Hydrothermal Vents. Marine Drugs. 2013; 11(5):1506-1523.
Martins, Ana; Tenreiro, Tania; Andrade, Gonçalo; Gadanho, Mário; Chaves, Sandra; Abrantes, Marta; Calado, Patrícia; Tenreiro, Rogério; Vieira, Helena. 2013. "Photoprotective Bioactivity Present in a Unique Marine Bacteria Collection from Portuguese Deep Sea Hydrothermal Vents." Mar. Drugs 11, no. 5: 1506-1523.