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Mar. Drugs 2013, 11(1), 33-39; doi:10.3390/md11010033
Communication

Isolation, Characterization, and Bioactivity Evaluation of 3-((6-Methylpyrazin-2-yl)methyl)-1H-indole, a New Alkaloid from a Deep-Sea-Derived Actinomycete Serinicoccus profundi sp. nov.

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Received: 15 October 2012; in revised form: 7 November 2012 / Accepted: 22 November 2012 / Published: 27 December 2012
(This article belongs to the Special Issue Deep-Sea Natural Products)
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Abstract: One new alkaloid, 3-((6-methylpyrazin-2-yl)methyl)-1H-indole (1) was obtained from the deep-sea actinomycete Serinicoccus profundi sp. nov., along with five known compounds (26). Their structures were determined on the basis of detailed analysis of the 1D and 2D NMR as well as MS data. The new indole alkaloid displayed weak antimicrobial activity against Staphylococcus aureus ATCC 25923 with an MIC value of 96 μg/mL. It showed no cytotoxicity on a normal human liver cell line (BEL7402) and a human liver tumor cell line (HL-7702).
Keywords: deep-sea sediment; actinomycete; Serinicoccus profundi sp. nov.; alkaloid; antibacterial activity; cytotoxicity deep-sea sediment; actinomycete; Serinicoccus profundi sp. nov.; alkaloid; antibacterial activity; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Yang, X.-W.; Zhang, G.-Y.; Ying, J.-X.; Yang, B.; Zhou, X.-F.; Steinmetz, A.; Liu, Y.-H.; Wang, N. Isolation, Characterization, and Bioactivity Evaluation of 3-((6-Methylpyrazin-2-yl)methyl)-1H-indole, a New Alkaloid from a Deep-Sea-Derived Actinomycete Serinicoccus profundi sp. nov.. Mar. Drugs 2013, 11, 33-39.

AMA Style

Yang X-W, Zhang G-Y, Ying J-X, Yang B, Zhou X-F, Steinmetz A, Liu Y-H, Wang N. Isolation, Characterization, and Bioactivity Evaluation of 3-((6-Methylpyrazin-2-yl)methyl)-1H-indole, a New Alkaloid from a Deep-Sea-Derived Actinomycete Serinicoccus profundi sp. nov.. Marine Drugs. 2013; 11(1):33-39.

Chicago/Turabian Style

Yang, Xian-Wen; Zhang, Gai-Yun; Ying, Jian-Xi; Yang, Bing; Zhou, Xue-Feng; Steinmetz, Andre; Liu, Yong-Hong; Wang, Ning. 2013. "Isolation, Characterization, and Bioactivity Evaluation of 3-((6-Methylpyrazin-2-yl)methyl)-1H-indole, a New Alkaloid from a Deep-Sea-Derived Actinomycete Serinicoccus profundi sp. nov.." Mar. Drugs 11, no. 1: 33-39.


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