Mar. Drugs 2012, 10(10), 2300-2311; doi:10.3390/md10102300
Article

Ammonificins C and D, Hydroxyethylamine Chromene Derivatives from a Cultured Marine Hydrothermal Vent Bacterium, Thermovibrio ammonificans

Eric H. Andrianasolo 1 email, Liti Haramaty 1 email, Richard Rosario-Passapera 1 email, Costantino Vetriani 1 email, Paul Falkowski 1 email, Eileen White 2 email and Richard Lutz 1,* email
1 Center for Marine Biotechnology, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA 2 Center for Advanced Biotechnology and Medicine, Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, 679 Hoes Lane, Piscataway, NJ 08854, USA
* Author to whom correspondence should be addressed.
Received: 30 July 2012; in revised form: 18 September 2012 / Accepted: 29 September 2012 / Published: 19 October 2012
(This article belongs to the Special Issue Deep-Sea Natural Products)
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Abstract: Chemical and biological investigation of the cultured marine hydrothermal vent bacterium, Thermovibrio ammonifican led to the isolation of two hydroxyethylamine chromene derivatives, ammonificins C and D. Their structures were elucidated using combination of NMR and mass spectrometry. Absolute stereochemistry was ascertained by comparison of experimental and calculated CD spectra. Biological evaluation and assessment were determined using the patented ApopScreen cell-based screen for apoptosis-induction. Ammonificins C and D induce apoptosis in micromolar concentrations. To our knowledge, this finding is the first report of chemical compounds that induce apoptosis from the cultured deep-sea marine organism, hydrothermal vent bacterium, Thermovibrio ammonificans.
Keywords: marine natural product; deep-sea hydrothermal vent; drug discovery; induction of apoptosis; bacteria; computational methods

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MDPI and ACS Style

Andrianasolo, E.H.; Haramaty, L.; Rosario-Passapera, R.; Vetriani, C.; Falkowski, P.; White, E.; Lutz, R. Ammonificins C and D, Hydroxyethylamine Chromene Derivatives from a Cultured Marine Hydrothermal Vent Bacterium, Thermovibrio ammonificans. Mar. Drugs 2012, 10, 2300-2311.

AMA Style

Andrianasolo EH, Haramaty L, Rosario-Passapera R, Vetriani C, Falkowski P, White E, Lutz R. Ammonificins C and D, Hydroxyethylamine Chromene Derivatives from a Cultured Marine Hydrothermal Vent Bacterium, Thermovibrio ammonificans. Marine Drugs. 2012; 10(10):2300-2311.

Chicago/Turabian Style

Andrianasolo, Eric H.; Haramaty, Liti; Rosario-Passapera, Richard; Vetriani, Costantino; Falkowski, Paul; White, Eileen; Lutz, Richard. 2012. "Ammonificins C and D, Hydroxyethylamine Chromene Derivatives from a Cultured Marine Hydrothermal Vent Bacterium, Thermovibrio ammonificans." Mar. Drugs 10, no. 10: 2300-2311.

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