Mar. Drugs 2013, 11(4), 1399-1408; doi:10.3390/md11041399
Article

Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1

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Received: 28 January 2013; in revised form: 25 March 2013 / Accepted: 7 April 2013 / Published: 23 April 2013
(This article belongs to the Special Issue Deep-Sea Natural Products)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A new chloro-trinoreremophilane sesquiterpene 1, three new chlorinated eremophilane sesquiterpenes 24, together with a known compound, eremofortine C (5), were isolated from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Structures were established using IR, HRMS, 1D and 2D NMR techniques. In addition, the plausible metabolic network of these isolated products is proposed. Compound 1 showed moderate cytotoxic activity against HL-60 and A549 cancer cell lines.
Keywords: chlorinated eremophilane sesquiterpene; Antarctic deep-sea derived fungus; Penicillium sp.
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MDPI and ACS Style

Wu, G.; Lin, A.; Gu, Q.; Zhu, T.; Li, D. Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1. Mar. Drugs 2013, 11, 1399-1408.

AMA Style

Wu G, Lin A, Gu Q, Zhu T, Li D. Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1. Marine Drugs. 2013; 11(4):1399-1408.

Chicago/Turabian Style

Wu, Guangwei; Lin, Aiqun; Gu, Qianqun; Zhu, Tianjiao; Li, Dehai. 2013. "Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1." Mar. Drugs 11, no. 4: 1399-1408.

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