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Mar. Drugs 2013, 11(5), 1524-1533; doi:10.3390/md11051524

Tetroazolemycins A and B, Two New Oxazole-Thiazole Siderophores from Deep-Sea Streptomyces olivaceus FXJ8.012

1 State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China 2 Analytical and Testing Center, Beijing University of Chemical Technology, Beijing 100029, China
* Author to whom correspondence should be addressed.
Received: 16 February 2013 / Revised: 18 April 2013 / Accepted: 24 April 2013 / Published: 10 May 2013
(This article belongs to the Special Issue Deep-Sea Natural Products)
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Two new oxazole/thiazole derivatives, named tetroazolemycins A (1) and B (2), have been isolated from the acetone extract of the mycelium of Streptomyces olivaceus FXJ8.012 derived from deep-sea water, together with three known compounds, spoxazomicins A–C (35), isolated from the fermentation supernatant. The planar structure and relative configuration of tetroazolemycins were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR techniques, and showed to be new pyochelin-type antibiotics. Both compounds showed metal ion-binding activity and their Zn2+ complexes exhibited weak activity against pathogenic bacteria Klebsiella pneumoniae.
Keywords: deep-sea water; Streptomyces olivaceus; tetroazolemycin; siderophore deep-sea water; Streptomyces olivaceus; tetroazolemycin; siderophore
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Liu, N.; Shang, F.; Xi, L.; Huang, Y. Tetroazolemycins A and B, Two New Oxazole-Thiazole Siderophores from Deep-Sea Streptomyces olivaceus FXJ8.012. Mar. Drugs 2013, 11, 1524-1533.

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