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Mar. Drugs 2013, 11(5), 1524-1533; doi:10.3390/md11051524
Article

Tetroazolemycins A and B, Two New Oxazole-Thiazole Siderophores from Deep-Sea Streptomyces olivaceus FXJ8.012

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Received: 16 February 2013; in revised form: 18 April 2013 / Accepted: 24 April 2013 / Published: 10 May 2013
(This article belongs to the Special Issue Deep-Sea Natural Products)
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Abstract: Two new oxazole/thiazole derivatives, named tetroazolemycins A (1) and B (2), have been isolated from the acetone extract of the mycelium of Streptomyces olivaceus FXJ8.012 derived from deep-sea water, together with three known compounds, spoxazomicins A–C (35), isolated from the fermentation supernatant. The planar structure and relative configuration of tetroazolemycins were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR techniques, and showed to be new pyochelin-type antibiotics. Both compounds showed metal ion-binding activity and their Zn2+ complexes exhibited weak activity against pathogenic bacteria Klebsiella pneumoniae.
Keywords: deep-sea water; Streptomyces olivaceus; tetroazolemycin; siderophore deep-sea water; Streptomyces olivaceus; tetroazolemycin; siderophore
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Liu, N.; Shang, F.; Xi, L.; Huang, Y. Tetroazolemycins A and B, Two New Oxazole-Thiazole Siderophores from Deep-Sea Streptomyces olivaceus FXJ8.012. Mar. Drugs 2013, 11, 1524-1533.

AMA Style

Liu N, Shang F, Xi L, Huang Y. Tetroazolemycins A and B, Two New Oxazole-Thiazole Siderophores from Deep-Sea Streptomyces olivaceus FXJ8.012. Marine Drugs. 2013; 11(5):1524-1533.

Chicago/Turabian Style

Liu, Ning; Shang, Fei; Xi, Lijun; Huang, Ying. 2013. "Tetroazolemycins A and B, Two New Oxazole-Thiazole Siderophores from Deep-Sea Streptomyces olivaceus FXJ8.012." Mar. Drugs 11, no. 5: 1524-1533.


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