Special Issue "Advances in Ophthalmic Biomaterials"
A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).
Deadline for manuscript submissions: closed (31 March 2013)
Prof. Dr. Heather Sheardown
Department of Chemical Engineering, McMaster University, Room JHE-124A, 1280 Main Street West, Hamilton, Ontario, L8S 4L7, Canada
Phone: +1 905 525 9140 (ext.24794)
Interests: ophthalmic biomaterials; ophthalmic drug delivery; polymers; surface modification; protein adsorption; cell material interactions; hydrogels; contact lenses; intraocular lenses
Dr. Traian V. Chirila
Queensland Eye Institute, 41 Annerley Road, South Brisbane, Qld. 4101, Australia
Interests: development of polymer substrates for cellular growth; biodegradable hydrogels; calcification of hydrogels; interpenetrating polymers networks; artificial vitreous substitutes; self-healing hydrogels; tissue engineering; ocular surface reconstruction; controlled release of bioactive agents; artificial corneal endothelium
After half of a century, the field of ophthalmic biomaterials has become firmly established as an integral and essential part of the ocular tissue engineering and regenerative ophthalmology. Biomaterials, either modified biopolymers or synthetic polymers, are used as replacements for various damaged ocular elements. Such replacements include artificial intraocular lenses, artificial corneas and corneal elements, vitreous substitutes, tube systems and canaliculi for glaucoma and lacrimal surgery, carriers for sustained release of ocular drugs, surgical adhesives, viscoelastics for ocular surgery etc. Going beyond prosthetic replacements and devices, novel types of ophthalmic biomaterials are currently being developed by manipulating both bulk structure and surface of materials to provide more complex systems able to play a role in the stimulation of target cells with an aim to heal and regenerate damaged ocular tissue. Such biomaterials serve for the creation of tissue-engineered constructs that are used in new regenerative strategies that are advanced for the treatment of eye disease and trauma.
Prof. Dr. Heather Sheardown
Dr. Traian V. Chirila
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 300 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
- vitreous substitution
- ocular adhesives
- ocular surface reconstruction
- corneal tissue engineering
- retinal repair and regeneration
- substrata for ocular stem cells
J. Funct. Biomater. 2013, 4(1), 14-26; doi:10.3390/jfb4010014
Received: 1 November 2012; in revised form: 17 December 2012 / Accepted: 11 January 2013 / Published: 18 January 2013| Download PDF Full-text (2392 KB) | Download XML Full-text
Article: Cultivation of Human Microvascular Endothelial Cells on Topographical Substrates to Mimic the Human Corneal Endothelium
J. Funct. Biomater. 2013, 4(1), 38-58; doi:10.3390/jfb4010038
Received: 31 October 2012; in revised form: 30 January 2013 / Accepted: 25 February 2013 / Published: 21 March 2013| Download PDF Full-text (2714 KB) | Download XML Full-text
Article: Incorporation of Exogenous RGD Peptide and Inter-Species Blending as Strategies for Enhancing Human Corneal Limbal Epithelial Cell Growth on Bombyx mori Silk Fibroin Membranes
J. Funct. Biomater. 2013, 4(2), 74-88; doi:10.3390/jfb4020074 (doi registration under processing)
Received: 22 March 2013; in revised form: 6 May 2013 / Accepted: 6 May 2013 / Published: 17 May 2013| Download PDF Full-text (376 KB) | Download XML Full-text
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of Paper: Article
Title: Intraocular Lens Coating for PCO Prophylaxis
Authors: Eibl-Lindner KH, Liegl R, Wertheimer C and Kampik A.
Affiliation: Department of Ophthalmology, Ludwig-Maximilians-University, Mathildenstrasse 8 80336 Munich, Germany
Abstract: Posterior capsule opacification (PCO) represents the major long-term complication after cataract surgery. Intraocular lens (IOL) coating with pharmacologic substances could be an elegant approach to solve this problem. In this study, we investigated alkylphosphocholine-coated IOLs in a human anterior chamber model for PCO. Coated IOLs were placed on cell culture inserts (PET membrane uncoated/coated with collagen I or laminin) with proliferating human lens epithelial cells and the Tetrazolium Dye Reduction Assay was performed 5 days later. Alkylphosphocholines are novel compounds with antiproliferative properties and good ocular biocompatibility. They could serve as IOL coating agents for pharmacologic PCO prophylaxis in the future.
Last update: 2 November 2012