Abstract: The capsule drug ring (CDR) is a reservoir and delivery agent, which is designed to be placed within the capsular bag during cataract surgery. Prototypes were manufactured by hot melt extrusion of Bionate II®, a polycarbonate urethane. The devices have been optimized using Avastin® as the drug of interest. In vitro biocompatibility was assessed with human lens epithelial cell (B-3), mouse macrophage (J774A.1) and mouse fibroblast (L-929) cell lines. Cell migration and proliferation were assessed after in vitro culture. Pro-inflammatory cytokines (i.e., MIP-1β, MIP-1α, MCP-1, IL-1β, TNF and TGF-β1) were quantified using cytometric bead array (CBA). Preliminary in vivo biocompatibility and pharmacokinetics testing has been performed in rabbits.
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Gooch, N.; Burr, R.M.; Holt, D.J.; Gale, B.; Ambati, B. Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device. J. Funct. Biomater. 2013, 4, 14-26.
Gooch N, Burr RM, Holt DJ, Gale B, Ambati B. Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device. Journal of Functional Biomaterials. 2013; 4(1):14-26.
Gooch, Nathan; Burr, Randon M.; Holt, Dolly J.; Gale, Bruce; Ambati, Balamurali. 2013. "Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device." J. Funct. Biomater. 4, no. 1: 14-26.