Next Article in Journal
Heat Generation and Transfer Behaviors of Ti-Coated Carbon Steel Rod Adaptable for Ablation Therapy of Oral Cancer
Next Article in Special Issue
Cultivation of Human Microvascular Endothelial Cells on Topographical Substrates to Mimic the Human Corneal Endothelium
Previous Article in Journal
Use of an Ophthalmic Viscosurgical Device for Experimental Retinal Detachment in Rabbit Eyes
J. Funct. Biomater. 2013, 4(1), 14-26; doi:10.3390/jfb4010014
Article

Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device

1,* , 2
, 3
, 4
 and 2
1 Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA 2 Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA 3 Department of Cardiothoracic Surgery, University of Utah, Salt Lake City, UT 84112, USA 4 Department of Mechanical Engineering, University of Utah, Salt Lake City, UT 84112, USA
* Author to whom correspondence should be addressed.
Received: 1 November 2012 / Revised: 17 December 2012 / Accepted: 11 January 2013 / Published: 18 January 2013
(This article belongs to the Special Issue Advances in Ophthalmic Biomaterials)
View Full-Text   |   Download PDF [2392 KB, 22 January 2013; original version 18 January 2013]   |   Browse Figures

Abstract

The capsule drug ring (CDR) is a reservoir and delivery agent, which is designed to be placed within the capsular bag during cataract surgery. Prototypes were manufactured by hot melt extrusion of Bionate II®, a polycarbonate urethane. The devices have been optimized using Avastin® as the drug of interest. In vitro biocompatibility was assessed with human lens epithelial cell (B-3), mouse macrophage (J774A.1) and mouse fibroblast (L-929) cell lines. Cell migration and proliferation were assessed after in vitro culture. Pro-inflammatory cytokines (i.e., MIP-1β, MIP-1α, MCP-1, IL-1β, TNF and TGF-β1) were quantified using cytometric bead array (CBA). Preliminary in vivo biocompatibility and pharmacokinetics testing has been performed in rabbits.
Keywords: CDR; capsular bag; drug delivery; biocompatibility CDR; capsular bag; drug delivery; biocompatibility
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Gooch, N.; Burr, R.M.; Holt, D.J.; Gale, B.; Ambati, B. Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device. J. Funct. Biomater. 2013, 4, 14-26.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert