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J. Funct. Biomater. 2013, 4(1), 14-26; doi:10.3390/jfb4010014

Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device

1,* , 2
Received: 1 November 2012 / Revised: 17 December 2012 / Accepted: 11 January 2013 / Published: 18 January 2013
(This article belongs to the Special Issue Advances in Ophthalmic Biomaterials)
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The capsule drug ring (CDR) is a reservoir and delivery agent, which is designed to be placed within the capsular bag during cataract surgery. Prototypes were manufactured by hot melt extrusion of Bionate II®, a polycarbonate urethane. The devices have been optimized using Avastin® as the drug of interest. In vitro biocompatibility was assessed with human lens epithelial cell (B-3), mouse macrophage (J774A.1) and mouse fibroblast (L-929) cell lines. Cell migration and proliferation were assessed after in vitro culture. Pro-inflammatory cytokines (i.e., MIP-1β, MIP-1α, MCP-1, IL-1β, TNF and TGF-β1) were quantified using cytometric bead array (CBA). Preliminary in vivo biocompatibility and pharmacokinetics testing has been performed in rabbits.
Keywords: CDR; capsular bag; drug delivery; biocompatibility CDR; capsular bag; drug delivery; biocompatibility
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Gooch, N.; Burr, R.M.; Holt, D.J.; Gale, B.; Ambati, B. Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device. J. Funct. Biomater. 2013, 4, 14-26.

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J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert