J. Funct. Biomater. 2013, 4(1), 14-26; doi:10.3390/jfb4010014
Article

Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device

1 Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA 2 Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA 3 Department of Cardiothoracic Surgery, University of Utah, Salt Lake City, UT 84112, USA 4 Department of Mechanical Engineering, University of Utah, Salt Lake City, UT 84112, USA
* Author to whom correspondence should be addressed.
Received: 1 November 2012; in revised form: 17 December 2012 / Accepted: 11 January 2013 / Published: 18 January 2013
(This article belongs to the Special Issue Advances in Ophthalmic Biomaterials)
PDF Full-text Download PDF Full-Text [2392 KB, Updated Version, uploaded 22 January 2013 15:47 CET]
The original version is still available [1008 KB, uploaded 18 January 2013 09:47 CET]
Abstract: The capsule drug ring (CDR) is a reservoir and delivery agent, which is designed to be placed within the capsular bag during cataract surgery. Prototypes were manufactured by hot melt extrusion of Bionate II®, a polycarbonate urethane. The devices have been optimized using Avastin® as the drug of interest. In vitro biocompatibility was assessed with human lens epithelial cell (B-3), mouse macrophage (J774A.1) and mouse fibroblast (L-929) cell lines. Cell migration and proliferation were assessed after in vitro culture. Pro-inflammatory cytokines (i.e., MIP-1β, MIP-1α, MCP-1, IL-1β, TNF and TGF-β1) were quantified using cytometric bead array (CBA). Preliminary in vivo biocompatibility and pharmacokinetics testing has been performed in rabbits.
Keywords: CDR; capsular bag; drug delivery; biocompatibility

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Gooch, N.; Burr, R.M.; Holt, D.J.; Gale, B.; Ambati, B. Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device. J. Funct. Biomater. 2013, 4, 14-26.

AMA Style

Gooch N, Burr RM, Holt DJ, Gale B, Ambati B. Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device. Journal of Functional Biomaterials. 2013; 4(1):14-26.

Chicago/Turabian Style

Gooch, Nathan; Burr, Randon M.; Holt, Dolly J.; Gale, Bruce; Ambati, Balamurali. 2013. "Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device." J. Funct. Biomater. 4, no. 1: 14-26.

J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert