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Tissue Engineering of the Corneal Endothelium: A Review of Carrier Materials
Leibniz Institute of Polymer Research Dresden, Max Bergmann Center of Biomaterials, Institute of Biofunctional Polymer Materials, Hohe Straße 6, Dresden 01069, Germany
Institute of Anatomy, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, Dresden 01307, Germany
CRTD/DFG-Center for Regenerative Therapies Dresden—Cluster of Excellence, Fetscherstraße 105, Dresden 01307, Germany
Department of Ophthalmology, Klinikum Chemnitz gGmbH, Flemmingstraße 2, Chemnitz 09116, Germany
These authors contribute equally to the work.
* Author to whom correspondence should be addressed.
Received: 3 August 2013; in revised form: 13 September 2013 / Accepted: 24 September 2013 / Published: 22 October 2013
Abstract: Functional impairment of the human corneal endothelium can lead to corneal blindness. In order to meet the high demand for transplants with an appropriate human corneal endothelial cell density as a prerequisite for corneal function, several tissue engineering techniques have been developed to generate transplantable endothelial cell sheets. These approaches range from the use of natural membranes, biological polymers and biosynthetic material compositions, to completely synthetic materials as matrices for corneal endothelial cell sheet generation. This review gives an overview about currently used materials for the generation of transplantable corneal endothelial cell sheets with a special focus on thermo-responsive polymer coatings.
Keywords: tissue engineering; corneal endothelium; corneal endothelial cell sheets; natural membranes; biological polymers; thermo-responsive polymers; physicochemical properties; biomolecular functionalization
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Teichmann, J.; Valtink, M.; Nitschke, M.; Gramm, S.; Funk, R.H.; Engelmann, K.; Werner, C. Tissue Engineering of the Corneal Endothelium: A Review of Carrier Materials. J. Funct. Biomater. 2013, 4, 178-208.
Teichmann J, Valtink M, Nitschke M, Gramm S, Funk RH, Engelmann K, Werner C. Tissue Engineering of the Corneal Endothelium: A Review of Carrier Materials. Journal of Functional Biomaterials. 2013; 4(4):178-208.
Teichmann, Juliane; Valtink, Monika; Nitschke, Mirko; Gramm, Stefan; Funk, Richard H.; Engelmann, Katrin; Werner, Carsten. 2013. "Tissue Engineering of the Corneal Endothelium: A Review of Carrier Materials." J. Funct. Biomater. 4, no. 4: 178-208.