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Int. J. Mol. Sci. 2012, 13(8), 10268-10295; doi:10.3390/ijms130810268
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Biogenesis and Mechanism of Action of Small Non-Coding RNAs: Insights from the Point of View of Structural Biology

1
, 2
 and 1,*
Received: 30 May 2012 / Revised: 17 July 2012 / Accepted: 2 August 2012 / Published: 17 August 2012
(This article belongs to the Special Issue Protein Crystallography in Molecular Biology)
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Abstract

Non-coding RNAs are dominant in the genomic output of the higher organisms being not simply occasional transcripts with idiosyncratic functions, but constituting an extensive regulatory network. Among all the species of non-coding RNAs, small non-coding RNAs (miRNAs, siRNAs and piRNAs) have been shown to be in the core of the regulatory machinery of all the genomic output in eukaryotic cells. Small non-coding RNAs are produced by several pathways containing specialized enzymes that process RNA transcripts. The mechanism of action of these molecules is also ensured by a group of effector proteins that are commonly engaged within high molecular weight protein-RNA complexes. In the last decade, the contribution of structural biology has been essential to the dissection of the molecular mechanisms involved in the biosynthesis and function of small non-coding RNAs.
Keywords: non-coding RNA; structural biology; X-ray crystallography; microprocessor; miRNAs; Dicer; DGCR8; argonaute non-coding RNA; structural biology; X-ray crystallography; microprocessor; miRNAs; Dicer; DGCR8; argonaute
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Costa, M.C.; Leitão, A.L.; Enguita, F.J. Biogenesis and Mechanism of Action of Small Non-Coding RNAs: Insights from the Point of View of Structural Biology. Int. J. Mol. Sci. 2012, 13, 10268-10295.

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