Special Issue "Bioactive Lipids and Lipidomics"
Deadline for manuscript submissions: 30 June 2014
Prof. Dr. Mario Ollero
Université Paris Est Créteil, INSERM, U955, Créteil, France
Interests: lipidomics; proteomics; nephrology; immunology; nephrotic syndrome; membrane microdomains; membrane dynamics; lipid signaling
Recent advances in technologies for lipid analysis have contributed to the consolidation of lipidomics as a distinct discipline in molecular science. This technological development has paralleled the discovery of a broad range of cellular functions associated with lipids, from cell signaling and membrane dynamics, to intercellular communication and the regulation of gene expression. Lipid molecules have been identified as therapeutic targets, nutraceuticals and disease biomarkers.
The scope of this special issue is to cover the progress in Lipid Science & Technology, with regard to the state-of-the-art research in bioactive lipids and lipidomics.
Authors are invited to submit original research and review articles. Topics include, but are not limited to:
- Bioactive lipids in cell biology
- Lipid molecules as therapeutic agents and nutraceuticals
- Lipids as diagnostic and prognostic biomarkers of disease
- New advances in lipid analysis and lipidomics
- Lipids in systems biology and metabolic networks
Prof. Dr. Mario Ollero
Prof. Dr. Giuseppe Astarita
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.
- systems biology
- lipid signaling
- lipid ligands
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of Paper: Article
Title: Effect of Sibutramine and High Fat Diet on Body Fat Composition in F344 Rats by in Vivo Magnetic Resonance Imaging and Spectroscopy
Author: S. Sendhil Velan
Affiliation: Singapore Bioimaging Consortium, Singapore 138667
Abstract: Current treatments for obesity have limited efficacy and are focused in reducing the body weight or visceral fat which takes longer duration to show effect. In this study, we investigated the fat metabolism in rats fed a high fat diet, and its response to diet and drug, using magnetic resonance imaging (MRI) and spectroscopy (MRS) and blood chemistry. The high fat diet supplementation significantly increased triglycerides (TG) and insulin levels in blood plasma compared to control diet supplementation. The body fat analysis of high fat diet group showed a significant increase in liver fat , intramyocellular lipid (IMCL) and visceral fat compared to the control group. In evaluation of anti-obesity processes, TG concentration decreased on day 1 and 3 compared to day 0 in Sibutramine treated group. The Sibutramine drug treated group showed rapid reduction of liver fat and IMCL on day 3. Our findings demonstrate that 1H-MRS and MRI can be utilized to follow the adiposity in organs including liver, abdomen and skeletal muscle during obesity and also during anti-obesity interventions.
Type of Paper: Article
Title: Synthesis of conjugated linoleic acid by food-derived lactobacill
Authors: Bo Yang1,2, Haiqin Chen1,2,*, Zhennan Gu1,2, Fengwei Tian1,2, R. Paul Ross3,4, Catherine Stanton3,4, Yong Q. Chen1,2,5, Wei Chen1,2 and Hao Zhang1,2,*
Affiliations: 1. State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China;
2. Synergetic Innovation Center of Food Safety and Nutrition, Wuxi, China
3. Teagasc Moorepark Food Research Centre, Fermoy, Co. Cork, Ireland
4. Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
5. Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA
Abstract:Conjugated linoleic acid (CLA) has attracted increased research interest because of its biologically functions. A selection of food-derived lactobacilli were assessed for the ability to produce conjugated linoleic acid from free linoleic acid. Most of the assessed strains produced CLA at different levels. The most efficient CLA producer converted over 50% of free linoleic acid to c9, t11-CLA and t9, t11-CLA. Some intermediates were determined via GC-MS. The genes coding the multi-component linoleate isomerase were cloned and expressed in Escherichia coli. With the mixture of recombinant E. coli as catalysts, c9, t11-CLA and three kinds of intermediates, which were in line with those from the lactobacilli, were produced from linoleic acid successfully.
Last update: 4 March 2014