Special Issue "Bioactive Lipids and Lipidomics"


A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (30 June 2014)

Special Issue Editors

Guest Editor
Prof. Dr. Mario Ollero
Université Paris Est Créteil, INSERM, U955, Créteil, France
E-Mail: mario.ollero@inserm.fr
Interests: lipidomics; proteomics; nephrology; immunology; nephrotic syndrome; membrane microdomains; membrane dynamics; lipid signaling

Guest Editor
Prof. Dr. Giuseppe Astarita
Georgetown University, Washington, DC, USA
Website: http://www.lipidomic.com
E-Mail: giuseppe_astarita@waters.com
Interests: lipidomics metabolomics nutrition

Special Issue Information

Dear Colleagues,

Recent advances in technologies for lipid analysis have contributed to the consolidation of lipidomics as a distinct discipline in molecular science. This technological development has paralleled the discovery of a broad range of cellular functions associated with lipids, from cell signaling and membrane dynamics, to intercellular communication and the regulation of gene expression. Lipid molecules have been identified as therapeutic targets, nutraceuticals and disease biomarkers.

The scope of this special issue is to cover the progress in Lipid Science & Technology, with regard to the state-of-the-art research in bioactive lipids and lipidomics.

Authors are invited to submit original research and review articles. Topics include, but are not limited to:

  • Bioactive lipids in cell biology
  • Lipid molecules as therapeutic agents and nutraceuticals
  • Lipids as diagnostic and prognostic biomarkers of disease
  • New advances in lipid analysis and lipidomics
  • Lipids in systems biology and metabolic networks

Prof. Dr. Mario Ollero
Prof. Dr. Giuseppe Astarita
Guest Editors


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs).


  • metabolomics
  • systems biology
  • nutraceuticals
  • biomarkers
  • lipid signaling
  • lipid ligands

Published Papers (3 papers)

by , , ,  and
Int. J. Mol. Sci. 2014, 15(7), 12807-12841; doi:10.3390/ijms150712807
Received: 11 May 2014; in revised form: 29 June 2014 / Accepted: 3 July 2014 / Published: 21 July 2014
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by , , ,  and
Int. J. Mol. Sci. 2014, 15(4), 5233-5245; doi:10.3390/ijms15045233
Received: 15 January 2014; in revised form: 12 March 2014 / Accepted: 18 March 2014 / Published: 25 March 2014
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abstract graphic

by , , ,  and
Int. J. Mol. Sci. 2014, 15(3), 4201-4220; doi:10.3390/ijms15034201
Received: 23 January 2014; in revised form: 19 February 2014 / Accepted: 21 February 2014 / Published: 10 March 2014
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abstract graphic

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Type of Paper: Article
: Synthesis of conjugated linoleic acid by food-derived lactobacill
Authors: Bo Yang1,2, Haiqin Chen1,2,*, Zhennan Gu1,2, Fengwei Tian1,2, R. Paul Ross3,4, Catherine Stanton3,4, Yong Q. Chen1,2,5, Wei Chen1,2 and Hao Zhang1,2,*
1State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China;
2Synergetic Innovation Center of Food Safety and Nutrition, Wuxi, China
3Teagasc Moorepark Food Research Centre, Fermoy, Co. Cork, Ireland
4Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
5Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA
:Conjugated linoleic acid (CLA) has attracted increased research interest because of its biologically functions. A selection of food-derived lactobacilli were assessed for the ability to produce conjugated linoleic acid from free linoleic acid. Most of the assessed strains produced CLA at different levels. The most efficient CLA producer converted over 50% of free linoleic acid to c9, t11-CLA and t9, t11-CLA. Some intermediates were determined via GC-MS. The genes coding the multi-component linoleate isomerase were cloned and expressed in Escherichia coli. With the mixture of recombinant E. coli as catalysts, c9, t11-CLA and three kinds of intermediates, which were in line with those from the lactobacilli, were produced from linoleic acid successfully.

Last update: 4 June 2014

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