Next Article in Journal
Prognostic DNA Methylation Markers for Prostate Cancer
Next Article in Special Issue
FT-IR Microspectrometry Reveals the Variation of Membrane Polarizability due to Epigenomic Effect on Epithelial Ovarian Cancer
Previous Article in Journal
Structure Elucidation and Cytotoxic Evaluation of New Polyacetylenes from a Marine Sponge Petrosia sp.
Previous Article in Special Issue
Are Sensory TRP Channels Biological Alarms for Lipid Peroxidation?
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2014, 15(9), 16522-16543; doi:10.3390/ijms150916522

Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid

Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 24 July 2014 / Revised: 21 August 2014 / Accepted: 11 September 2014 / Published: 18 September 2014
(This article belongs to the Special Issue Bioactive Lipids and Lipidomics)
View Full-Text   |   Download PDF [1135 KB, uploaded 18 September 2014]   |  

Abstract

Bile acids are cholesterol-derived bioactive lipids that play essential roles in the maintenance of a heathy lifespan. These amphipathic molecules with detergent-like properties display numerous beneficial effects on various longevity- and healthspan-promoting processes in evolutionarily distant organisms. Recent studies revealed that lithocholic bile acid not only causes a considerable lifespan extension in yeast, but also exhibits a substantial cytotoxic effect in cultured cancer cells derived from different tissues and organisms. The molecular and cellular mechanisms underlying the robust anti-aging and anti-tumor effects of lithocholic acid have emerged. This review summarizes the current knowledge of these mechanisms, outlines the most important unanswered questions and suggests directions for future research. View Full-Text
Keywords: bioactive lipids; lipid metabolism; lipidomics; bile acids; aging and age-related diseases; cancer; anti-aging and anti-tumor therapeutic agents; endoplasmic reticulum; mitochondria; cell death bioactive lipids; lipid metabolism; lipidomics; bile acids; aging and age-related diseases; cancer; anti-aging and anti-tumor therapeutic agents; endoplasmic reticulum; mitochondria; cell death
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Arlia-Ciommo, A.; Piano, A.; Svistkova, V.; Mohtashami, S.; Titorenko, V.I. Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid. Int. J. Mol. Sci. 2014, 15, 16522-16543.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top