Next Article in Journal
Peripheral Blood Lymphocyte Subsets (CD4+, CD8+ T Cells, NK Cells) in Patients with Cardiovascular and Neurological Complications after Carotid Endarterectomy
Next Article in Special Issue
Untargeted Metabolomics Reveals Predominant Alterations in Lipid Metabolism Following Light Exposure in Broccoli Sprouts
Previous Article in Journal
Nitrogen Removal Characteristics of a Newly Isolated Indigenous Aerobic Denitrifier from Oligotrophic Drinking Water Reservoir, Zoogloea sp. N299
Previous Article in Special Issue
Lipidomics: An Evolving Discipline in Molecular Sciences
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2015, 16(5), 10061-10076; doi:10.3390/ijms160510061

Autistic Children Exhibit Decreased Levels of Essential Fatty Acids in Red Blood Cells

1
Laboratory of Lipid Medicine and Technology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
2
Genetics Diagnostic Lab, Department of Laboratory Medicine and Pathology, Children's Hospital Boston and Harvard Medical School, Boston, MA 02114, USA
3
Department of Pharmaceutical Science, North Dakota State University, Fargo, ND 58108, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Giuseppe Astarita
Received: 27 February 2015 / Revised: 19 April 2015 / Accepted: 29 April 2015 / Published: 4 May 2015
(This article belongs to the Special Issue Bioactive Lipids and Lipidomics)
View Full-Text   |   Download PDF [1030 KB, uploaded 4 May 2015]   |  

Abstract

Omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids (PUFA) are essential nutrients for brain development and function. However, whether or not the levels of these fatty acids are altered in individuals with autism remains debatable. In this study, we compared the fatty acid contents between 121 autistic patients and 110 non-autistic, non-developmentally delayed controls, aged 3–17. Analysis of the fatty acid composition of red blood cell (RBC) membrane phospholipids showed that the percentage of total PUFA was lower in autistic patients than in controls; levels of n-6 arachidonic acid (AA) and n-3 docosahexaenoic acid (DHA) were particularly decreased (p < 0.001). In addition, plasma levels of the pro-inflammatory AA metabolite prostaglandin E2 (PGE2) were higher in a subset of the autistic participants (n = 20) compared to controls. Our study demonstrates an alteration in the PUFA profile and increased production of a PUFA-derived metabolite in autistic patients, supporting the hypothesis that abnormal lipid metabolism is implicated in autism. View Full-Text
Keywords: polyunsaturated fatty acids; omega-6 and omega-3 fatty acids; prostaglandin E2; lipid metabolism; neuroinflammation; autism polyunsaturated fatty acids; omega-6 and omega-3 fatty acids; prostaglandin E2; lipid metabolism; neuroinflammation; autism
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Brigandi, S.A.; Shao, H.; Qian, S.Y.; Shen, Y.; Wu, B.-L.; Kang, J.X. Autistic Children Exhibit Decreased Levels of Essential Fatty Acids in Red Blood Cells. Int. J. Mol. Sci. 2015, 16, 10061-10076.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top