Special Issue "Genetics of Diabetes"
A special issue of Genes (ISSN 2073-4425).
Deadline for manuscript submissions: 15 July 2013
Dr. Claire Vandiedonck
Inserm UMR-S-958 "Genetics of diabetes", University Paris Diderot - Paris 7, School of Medicine, Site Villemin, 10 avenue de Verdun, 75010 Paris, France
Phone: +33 157278555
Interests: immunogenetics; MHC; autoimmunity; type 1 diabetes; eQTL mapping; multifactorial genetics
Genetic studies, including genome-wide linkage and association studies, have been a main component of research strategies aiming at understanding the pathogenesis of various forms of diabetes. Type 1 and type 2 diabetes benefited from consortia screening large cohorts using various polymorphisms (microsatellites, SNPs and CNVs), from common to rare. For other “specific” forms of diabetes (neonatal, syndromic or atypical), characterization of homogeneous phenotypes through linkage was crucial. However, despite intensive studies, the identification of the causative variants or mutations remains challenging and the molecular mechanisms are still rarely characterized. The achievement of next-generation-sequencing technologies applied to the search for DNA variants or aiming at characterizing functional elements, as examplified by the recent ENCODE project, opens a promising era to decipher the genetic bases of diabetes, to help better understand pathogenetic mechanisms, hopefully leading to personalized medicine.
This Special Issue of “Genes” welcomes reviews and original papers covering recent genetic research on any type of diabetes, either multifactorial or monogenic, both in man and in animal models, using high-throughput omic approaches. Special interest will be given to integrative biology studies.
Dr. Claire Vandiedonck
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 300 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
- next-generation sequencing
- chromatin studies
- integrative biology
- molecular function
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: The Genetics of Diabetic Nephropathy
Authors: Eoin Brennan 1, Denise Sadlier 2, Catherine Godson 1 and Finian Martin 1
Affiliations: 1 Diabetes Complications Research Centre, Conway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland
2 Mater Misericordiae Hospital, Dublin, Ireland; E-Mail: firstname.lastname@example.org
Abstract: Up to 40% of patients with type 1 and type 2 diabetes will develop diabetic nephropathy (DN), resulting in significant kidney damage and ultimately renal failure. There is evidence for a heritable genetic susceptibility to DN, but despite intensive research efforts the causative genes remain elusive. Recently, genome-wide association studies have discovered several novel genetic variants associated with DN. The identification of such causal and protective variants may potentially allow for early identification of at risk patients. Here we review the current understanding of the genetic architecture of DN, and discuss the merits of employing an integrative approach to incorporate datasets from multiple sources (genetics, transcriptomics, proteomics, experimental models) in order to fully elucidate the genetic elements contributing to this serious complication of diabetes.
Last update: 27 March 2013