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Genes 2013, 4(4), 596-619; doi:10.3390/genes4040596

The Genetics of Diabetic Nephropathy

1
Diabetes Complications Research Centre, Conway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland
2
Mater Misericordiae Hospital, Dublin, Ireland
3
Conway Institute of Biomolecular and Biomedical Research, School of Biomolecular and Biomedical Sciences, University College Dublin, Dublin, Ireland
*
Author to whom correspondence should be addressed.
Received: 18 July 2013 / Revised: 8 October 2013 / Accepted: 30 October 2013 / Published: 5 November 2013
(This article belongs to the Special Issue Genetics of Diabetes)
View Full-Text   |   Download PDF [415 KB, uploaded 5 November 2013]   |  

Abstract

Up to 40% of patients with type 1 and type 2 diabetes will develop diabetic nephropathy (DN), resulting in chronic kidney disease and potential organ failure. There is evidence for a heritable genetic susceptibility to DN, but despite intensive research efforts the causative genes remain elusive. Recently, genome-wide association studies have discovered several novel genetic variants associated with DN. The identification of such variants may potentially allow for early identification of at risk patients. Here we review the current understanding of the key molecular mechanisms and genetic architecture of DN, and discuss the merits of employing an integrative approach to incorporate datasets from multiple sources (genetics, transcriptomics, epigenetic, proteomic) in order to fully elucidate the genetic elements contributing to this serious complication of diabetes.
Keywords: diabetes mellitus; diabetic nephropathy; genome-wide association study; single nucleotide polymorphism diabetes mellitus; diabetic nephropathy; genome-wide association study; single nucleotide polymorphism
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Brennan, E.; McEvoy, C.; Sadlier, D.; Godson, C.; Martin, F. The Genetics of Diabetic Nephropathy. Genes 2013, 4, 596-619.

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