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Genes 2015, 6(2), 372-384; doi:10.3390/genes6020372

Genetics of Type 2 Diabetes and Clinical Utility

1
Genome Institute of Singapore, Agency for Science, Technology and Research, 138672, Singapore
2
Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore
3
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore
4
Imperial College London, London, SW7 2AZ, UK
5
Department of Endocrinology, Tan Tock Seng Hospital, Singapore 308433, Singapore
*
Author to whom correspondence should be addressed.
Academic Editor: Claire Vandiedonck
Received: 16 April 2015 / Revised: 2 June 2015 / Accepted: 11 June 2015 / Published: 23 June 2015
(This article belongs to the Special Issue Genetics of Diabetes)
View Full-Text   |   Download PDF [107 KB, uploaded 23 June 2015]

Abstract

A large proportion of heritability of type 2 diabetes (T2D) has been attributed to inherent genetics. Recent genetic studies, especially genome-wide association studies (GWAS), have identified a multitude of variants associated with T2D. It is thus reasonable to question if these findings may be utilized in a clinical setting. Here we briefly review the identification of risk loci for T2D and discuss recent efforts and propose future work to utilize these loci in clinical setting—for the identification of individuals who are at particularly high risks of developing T2D and for the stratification of specific health-care approaches for those who would benefit most from such interventions. View Full-Text
Keywords: type 2 diabetes; genetics; clinical utility type 2 diabetes; genetics; clinical utility
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Dorajoo, R.; Liu, J.; Boehm, B.O. Genetics of Type 2 Diabetes and Clinical Utility. Genes 2015, 6, 372-384.

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