Alu Elements as Novel Regulators of Gene Expression in Type 1 Diabetes Susceptibility Genes?
AbstractDespite numerous studies implicating Alu repeat elements in various diseases, there is sparse information available with respect to the potential functional and biological roles of the repeat elements in Type 1 diabetes (T1D). Therefore, we performed a genome-wide sequence analysis of T1D candidate genes to identify embedded Alu elements within these genes. We observed significant enrichment of Alu elements within the T1D genes (p-value < 10e−16), which highlights their importance in T1D. Functional annotation of T1D genes harboring Alus revealed significant enrichment for immune-mediated processes (p-value < 10e−6). We also identified eight T1D genes harboring inverted Alus (IRAlus) within their 3' untranslated regions (UTRs) that are known to regulate the expression of host mRNAs by generating double stranded RNA duplexes. Our in silico analysis predicted the formation of duplex structures by IRAlus within the 3'UTRs of T1D genes. We propose that IRAlus might be involved in regulating the expression levels of the host T1D genes. View Full-Text
- Supplementary File 1:
Supplementary (PDF, 511 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Kaur, S.; Pociot, F. Alu Elements as Novel Regulators of Gene Expression in Type 1 Diabetes Susceptibility Genes? Genes 2015, 6, 577-591.
Kaur S, Pociot F. Alu Elements as Novel Regulators of Gene Expression in Type 1 Diabetes Susceptibility Genes? Genes. 2015; 6(3):577-591.Chicago/Turabian Style
Kaur, Simranjeet; Pociot, Flemming. 2015. "Alu Elements as Novel Regulators of Gene Expression in Type 1 Diabetes Susceptibility Genes?" Genes 6, no. 3: 577-591.