Special Issue "Advances in Medical Device Coatings"
A special issue of Coatings (ISSN 2079-6412).
Deadline for manuscript submissions: closed (20 September 2013)
Dr. Denis Dowling
Surface Engineering Research Group, Room 223, UCD Engineering and Materials Science Centre, University College Dublin, Belfield, Dublin 4, Ireland
Phone: +353 (0)1 716 1747/1884/1787
Fax: +353 (0)1 283 0534
Interests: coatings; atmospheric plasmas; cell adhesion; medical devices; tailored surface chemistry
There has been an enormous growth in the application of coatings onto medical devices in the last few years. Examples of these coatings range from hydroxyapetite, which enhance cell attachment onto orthopaedic implants, to antimicrobial silver coatings on catheters, drug eluting coatings on stents and blood compatible coatings such as heparin. These coatings are deposited using processes such as plasma spraying, dipping and spin coating. More recently novel coating techniques such as laser treatments, low temperature atmospheric plasmas and microblasting techniques have also been developed for the deposition of bioactive coatings. The objective of this review is to highlight new developments in the deposition and characterisation of coatings for both implantable and non-implantable medical device applications. Issues such as how the presence of specific chemical functionalities or coating morphology influences protein and / or cell adhesion or anti-microbial activity will be considered. Developing methods of assessing the potential longer term stability (ageing) issues associated with coated devices are critically important prior to the clinical application of these devices. Included also in this review are both in-vitro and in-vivo studies on the performance of both novel coatings and / or processing technologies.
Dr. Denis Dowling
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Coatings is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. For the first couple of issues the Article Processing Charge (APC) will be waived for well-prepared manuscripts. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
- thin film
- chemical functionality
- cell attachment
- surface treatment
Coatings 2011, 1(1), 53-71; doi:10.3390/coatings1010053
Received: 16 July 2011; in revised form: 23 August 2011 / Accepted: 1 September 2011 / Published: 13 September 2011| Download PDF Full-text (1194 KB) | Download XML Full-text
Article: Biocompatibility of Niobium Coatings
Coatings 2011, 1(1), 72-87; doi:10.3390/coatings1010072
Received: 2 August 2011; in revised form: 1 September 2011 / Accepted: 15 September 2011 / Published: 22 September 2011| Download PDF Full-text (1391 KB) | Download XML Full-text
Coatings 2012, 2(1), 45-63; doi:10.3390/coatings2010045
Received: 16 December 2011; in revised form: 20 February 2012 / Accepted: 22 February 2012 / Published: 27 February 2012| Download PDF Full-text (1639 KB) | Download XML Full-text
Article: Development and in Vitro Characterization of Photochemically Crosslinked Polyvinylpyrrolidone Coatings for Drug-Coated Balloons
Coatings 2013, 3(4), 253-267; doi:10.3390/coatings3040253 (doi registration under processing)
Received: 20 September 2013; in revised form: 7 November 2013 / Accepted: 27 November 2013 / Published: 5 December 2013| Download PDF Full-text (764 KB) | Download XML Full-text
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of Paper: Article
Title: Biomedical Nanoparticle Surfaces: Insights into Immune-Compatibility
Authors: Olimpia Gamucci, Alice Bertero, Mariacristina Gagliardi and Giuseppe Bardi *
Affiliation: Center for MicroBioRobotics @SSSA, Istituto Italiano di Tecnologia, Viale Rinaldo Piaggio 34, 56025 Pontedera, Italy; * E-Mail: Giuseppe.Bardi@iit.it (G.B.)
Abstract: Diagnostic- and therapeutic release-aimed nanoparticles require the highest degree of biocompatibility. Some physical and chemical characteristics of such nanomaterials are often at odds with this requirement. For instance, metals with specific features used as contrast agents in magnetic resonance imaging need particular coatings to improve their blood solubility and increase their biocompatibility. Other examples come from the development of nanocarriers exploiting the different characteristics of two or more materials, i.e., the ability to encapsulate a certain drug by one core-material and the targeting capability of a different coating surface. Furthermore, all these “human-non-self” modifications necessitate proofs of compatibility with the immune system to avoid inflammatory reactions and resultant adverse effects for the patient. In the present review we discuss the molecular interactions and responses of the immune system to the principal nanoparticle surface modifications used in nanomedicine.
Type of Paper: Review
Title: Nano and Microscale Topographies for the Prevention of Bacterial Surface Fouling
Authors: Mary Graham and Nathaniel Cady
Affiliation: College of Nanoscale Science & Engineering (SUNY), Albany, NY, USA; E-Mails: firstname.lastname@example.org (M.G.); email@example.com (N.C.)
Abstract: Bacterial surface fouling is problematic for a wide range of applications and industries including medical devices (implants, replacement joints, stents, pacemakers, etc.), municipal infrastructure (pipes, wastewater treatment), food production (food processing surfaces, processing equipment), and transportation (ship hulls, aircraft fuel tanks, etc.). One method to combat bacterial biofouling is to modify the topographical structure of the surface in question, thereby limiting the ability of individual cells to attach to the surface. Multiple research groups, including our own, have demonstrated micro and nanoscale topographies that significantly reduce bacterial biofouling, for both individual cells and for bacterial biofilms. This review article will explore the various approaches to preparing engineered surface topographies, and the underlying physical properties of micro/nanoscale topographies that impact cell attachment.
Type of Paper: Article
Title: Comparison of Mechanical, Oxygen Permeation Barrier, Cytotoxical and Microbiological Properties of Ultrathin Diamond-Like Carbon Based and Silicon Oxide Films
Authors: Juergen M. Lackner 1, Claudia Meindl 2, Clemens Kittinger 3, Christian Teichert 4, Caterina-Marina Czibula 4, Lukasz Major 5, Alexander Fian 1, Elisabeth Martinelli 6, Wolfgang Waldhauser 1, Annelie Weinberg 7 and Eleonore Fröhlich 8,*
Affiliations: 1 Joanneum Research, Institute of Surface Technologies and Photonics, Functional Surfaces, Niklasdorf, Austria
2 Center for Medical Research, Medical University of Graz, Graz, Austria
3 Institute of Hygiene, Microbiology and Environmental Medicine, Medical University of Graz, Graz, Austria
4 University of Leoben, Institute of Physics, Leoben, Austria
5 Polish Academy of Sciences, Institute of Metallurgy and Materials Sciences, Krakow, Poland
6 Division of General Pediatric Surgery, Department of Orthopedic Surgery, Medical University of Graz, Graz, Austria
7 RU for Accident Research and Accident Prophylaxis, Department of Orthopedic Surgery, Medical University of Graz, Graz, Austria
8 Center for Medical Research, Medical University of Graz, Graz, Austria; * E-Mail: firstname.lastname@example.org
Abstract: Aim of the work was the benchmarking of mechanical oxygen permeation barrier, cytotoxical, and microbiological properties of inorganic ~25 nm thin films, deposited by vacuum deposition techniques on 50 µm thin polyetheretherketone (PEEK) foils. Plasma-activated chemical deposition using an ion source was applied to deposit pure and nitrogen doped diamond-like carbon film, while magnetron sputtering in pulsed DC mode was used for the growth of silicon as well as titanium doped diamond-like carbon films. Silicon oxide films were deposited by radio frequency magnetron sputtering. The results indicated for all coating types a strong influence by nanoporosity on the oxygen transmission rate, while the low content of microporosity (particulates, etc.) was shown to be of lower importance. Due to the thin foil substrates, allowing bending of the foil by low forces, the toughness of thin films as well as the elasticity index were proved to influence the oxygen barrier by prevention of film cracking. All investigated coatings are biocompatible with no cytotoxical effects in vitro as well as no influence on bacterial growth.
Last update: 13 August 2013