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Development and in Vitro Characterization of Photochemically Crosslinked Polyvinylpyrrolidone Coatings for Drug-Coated Balloons
Institute for Biomedical Engineering, University of Rostock, Friedrich-Barnewitz-Straße 4, 18119 Rostock, Germany
Bayer Material Science AG, BMS-CAS-INN, Leverkusen, Q 1, 212, Germany
* Author to whom correspondence should be addressed.
Received: 20 September 2013; in revised form: 7 November 2013 / Accepted: 27 November 2013 / Published: 5 December 2013
Abstract: Polyvinylpyrrolidone (PVP) is a conventionally applied hydrophilic lubricious coating on catheter-based cardiovascular devices, used in order to ease movement through the vasculature. Its use as drug reservoir and transfer agent on drug-coated balloons (DCB) is therefore extremely promising with regard to the simplification of its approval as a medical device. Here, we developed a PVP-based coating for DCB, containing paclitaxel (PTX) as a model drug, and studied the impact of crosslinking via UV radiation on drug stability, wash off, and transfer during simulated use in an in vitro vessel model. We showed that crosslinking was essential for coating stability and needed to be performed prior to PTX incorporation due to decreased drug bioavailability as a result of photodecomposition and/or involvement in vinylic polymerization with PVP under UV radiation. Moreover, the crosslinking time needed to be carefully controlled. While short radiation times did not provide enough coating stability, associated with high wash off rates during DCB insertion, long radiation times lowered drug transfer efficiency upon balloon expansion. A ten minutes radiation of PVP, however, combined a minimized drug wash off rate of 34% with an efficient drug transfer of 49%, underlining the high potential of photochemically crosslinked PVP as a coating matrix for DCB.
Keywords: implant coating; drug-coated balloons; hydrogel; drug delivery; crosslinking
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Petersen, S.; Minrath, I.; Kaule, S.; Köcher, J.; Schmitz, K.-P.; Sternberg, K. Development and in Vitro Characterization of Photochemically Crosslinked Polyvinylpyrrolidone Coatings for Drug-Coated Balloons. Coatings 2013, 3, 253-267.
Petersen S, Minrath I, Kaule S, Köcher J, Schmitz K-P, Sternberg K. Development and in Vitro Characterization of Photochemically Crosslinked Polyvinylpyrrolidone Coatings for Drug-Coated Balloons. Coatings. 2013; 3(4):253-267.
Petersen, Svea; Minrath, Ingo; Kaule, Sebastian; Köcher, Jürgen; Schmitz, Klaus-Peter; Sternberg, Katrin. 2013. "Development and in Vitro Characterization of Photochemically Crosslinked Polyvinylpyrrolidone Coatings for Drug-Coated Balloons." Coatings 3, no. 4: 253-267.