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Coatings 2011, 1(1), 72-87; doi:10.3390/coatings1010072

Biocompatibility of Niobium Coatings

1 Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA 2 Unidad de Materiales, Departamento de Ingeniería Mecánica y Mecátronica, Avenida 30 No. 45-03, Ciudad Unversitaria, Bototá D.C., Colombia 3 Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Circuito exterior SN, Ciudad Universitaria, 04510 México DF, México
* Author to whom correspondence should be addressed.
Received: 2 August 2011 / Revised: 1 September 2011 / Accepted: 15 September 2011 / Published: 22 September 2011
(This article belongs to the Special Issue Advances in Medical Device Coatings)
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Niobium coatings deposited by magnetron sputtering were evaluated as a possible surface modification for stainless steel (SS) substrates in biomedical implants. The Nb coatings were deposited on 15 mm diameter stainless steel substrates having an average surface roughness of 2 mm. To evaluate the biocompatibility of the coatings three different in vitro tests, using human alveolar bone derived cells, were performed: cellular adhesion, proliferation and viability. Stainless steel substrates and tissue culture plastic were also studied, in order to give comparative information. No toxic response was observed for any of the surfaces, indicating that the Nb coatings act as a biocompatible, bioinert material. Cell morphology was also studied by immune-fluorescence and the results confirmed the healthy state of the cells on the Nb surface. X-ray diffraction analysis of the coating shows that the film is polycrystalline with a body centered cubic structure. The surface composition and corrosion resistance of both the substrate and the Nb coating were also studied by X-ray photoelectron spectroscopy and potentiodynamic tests. Water contact angle measurements showed that the Nb surface is more hydrophobic than the SS substrate.
Keywords: niobium coatings; magnetron; osteoblasts; corrosion niobium coatings; magnetron; osteoblasts; corrosion
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Olivares-Navarrete, R.; Olaya, J.J.; Ramírez, C.; Rodil, S.E. Biocompatibility of Niobium Coatings. Coatings 2011, 1, 72-87.

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