Special Issue "Feature Paper"

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A special issue of Chemosensors (ISSN 2227-9040).

Deadline for manuscript submissions: closed (31 July 2015)

Special Issue Editor

Guest Editor
Dr. Igor Medintz (Website)

Laboratory for Biosensors and Biomaterials, Center for Biomolecular Science & Engineering, United States Naval Research Laboratory, Washington, D.C. USA
Fax: +1 202 7679594
Interests: nanoparticle-biological interface, energy transfer, FRET, biosensing, enzymatic catalysis at a nanoparticle interface, nanoparticle-based cellular imaging

Special Issue Information

Dear Colleagues,

We plan to publish a Special Issue on "feature papers" in order to give a broad overview of our area. We are looking for top quality papers which will be published free of charge in Open Access form. Authors will be the editorial board members and researchers invited by the editorial office and the Editor-in-Chief. Papers could be both extensive research papers and papers describing the current state of the art in one of the areas covered by the journal.

Prof. Dr. Igor Medintz
Guest Editor

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed Open Access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. For the first couple of issues the Article Processing Charge (APC) will be waived for well-prepared manuscripts. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.


Keywords

  • pH sensors, acid-base indicators
  • environment detectors, smoke detector
  • nanosensors
  • sensing materials
  • optical chemical sensors
  • biosensor and chemical sensors networks
  • medical analyzers
  • chemical field-effect transistors
  • new technologies with possibilities for chemosensing

Published Papers (4 papers)

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Research

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Open AccessArticle Electrochemical Sensors for the Estimation of the Inhibitory Effect of Phenylcarbamates to Cholinesterase
Chemosensors 2015, 3(4), 274-283; doi:10.3390/chemosensors3040274
Received: 9 October 2015 / Revised: 25 November 2015 / Accepted: 2 December 2015 / Published: 10 December 2015
Cited by 2 | PDF Full-text (460 KB) | HTML Full-text | XML Full-text
Abstract
The inhibitory effect of nine phenylcarbamates with various substituents was studied. For this purpose, electrochemical sensors were applied under two different conditions: if an enzyme was present in the solution or if the enzyme was immobilized onto the electrode surface. In both [...] Read more.
The inhibitory effect of nine phenylcarbamates with various substituents was studied. For this purpose, electrochemical sensors were applied under two different conditions: if an enzyme was present in the solution or if the enzyme was immobilized onto the electrode surface. In both cases, 3-[(ethoxycarbonyl)amino]phenyl (4-chloro-phenyl)carbamate was found as the most effective inhibitor for butyrylcholinesterase. The best inhibitors for acetylcholinesterase were determined as well, depending on the used method. Thus, 3‑[(butoxycarbonyl)-amino]phenyl phenylcarbamate with the enzyme present in the solution and 3-[(ethoxycarbonyl)amino]phenyl (3-methylphenyl)carbamate when the enzyme was immobilized onto the electrode surface were evaluated as the most effective inhibitors. Michaelis constants as well as maximum reaction rates were calculated and assessed. Full article
(This article belongs to the Special Issue Feature Paper)
Figures

Open AccessArticle Steady-State Fluorescence and Lifetime Emission Study of pH-Sensitive Probes Based on i-motif Forming Oligonucleotides Single and Double Labeled with Pyrene
Chemosensors 2015, 3(3), 211-223; doi:10.3390/chemosensors3030211
Received: 31 July 2015 / Accepted: 16 September 2015 / Published: 23 September 2015
Cited by 1 | PDF Full-text (895 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Cytosine-rich nucleic acids undergo pH-stimulated structural transitions leading to formation of an i-motif architecture at an acidic pH. Thus, i-motifs are good foundation for designing simple pH-sensitive fluorescent probes. We report here steady-state and time-resolved fluorescence studies of pyrene-labeled probes based on [...] Read more.
Cytosine-rich nucleic acids undergo pH-stimulated structural transitions leading to formation of an i-motif architecture at an acidic pH. Thus, i-motifs are good foundation for designing simple pH-sensitive fluorescent probes. We report here steady-state and time-resolved fluorescence studies of pyrene-labeled probes based on RET sequence: C4GC4GC4GC4TA (RET21), AC4GC4GC4GC4TA (RET21A) and C4GC4GC4GC4T (RET20). Comparative studies with single- and double-labeled i-motif probes were carried out. For each probe, we have measured fluorescence spectra and decays for emission wavelength of 390 nm over a wide range of pH (from 4.0 to 8.0). Effect of the oligonucleotide sequence and the number of pyrene labels on the spectral characteristics of probes were discussed. Full article
(This article belongs to the Special Issue Feature Paper)

Review

Jump to: Research

Open AccessReview New Nanomaterials and Luminescent Optical Sensors for Detection of Hydrogen Peroxide
Chemosensors 2015, 3(4), 253-273; doi:10.3390/chemosensors3040253
Received: 28 July 2015 / Revised: 23 September 2015 / Accepted: 20 October 2015 / Published: 26 October 2015
Cited by 1 | PDF Full-text (784 KB) | HTML Full-text | XML Full-text
Abstract
Accurate methods that can continuously detect low concentrations of hydrogen peroxide (H2O2) have a huge application potential in biological, pharmaceutical, clinical and environmental analysis. Luminescent probes and nanomaterials are used for fabrication of sensors for H2O [...] Read more.
Accurate methods that can continuously detect low concentrations of hydrogen peroxide (H2O2) have a huge application potential in biological, pharmaceutical, clinical and environmental analysis. Luminescent probes and nanomaterials are used for fabrication of sensors for H2O2 that can be applied for these purposes. In contrast to previous reviews focusing on the chemical design of molecular probes for H2O2, this mini-review highlights the latest luminescent nanoparticular materials and new luminescent optical sensors for H2O2 in terms of the nanomaterial composition and luminescent receptor used in the sensors. The nanomaterial section is subdivided into schemes based on gold nanoparticles, polymeric nanoparticles with embedded enzymes, probes showing aggregation-induced emission enhancement, quantum dots, lanthanide-based nanoparticles and carbon based nanomaterials, respectively. Moreover, the sensors are ordered according to the type of luminescent receptor used within the sensor membranes. Among them are lanthanide complexes, metal-ligand complexes, oxidic nanoparticles and organic dyes. Further, the optical sensors are confined to those that are capable to monitor the concentration of H2O2 in a sample over time or are reusable. Optical sensors responding to gaseous H2O2 are not covered. All nanomaterials and sensors are characterized with respect to the analytical reaction towards H2O2, limit of detection (LOD), analytical range, electrolyte, pH and response time/incubation time. Applications to real samples are given. Finally, we assess the suitability of the nanomaterials to be used in membrane-based sensors and discuss future trends and perspectives of these sensors in biomedical research. Full article
(This article belongs to the Special Issue Feature Paper)
Open AccessReview Novel Signal-Enhancing Approaches for Optical Detection of Nucleic Acids—Going beyond Target Amplification
Chemosensors 2015, 3(3), 224-240; doi:10.3390/chemosensors3030224
Received: 10 August 2015 / Accepted: 16 September 2015 / Published: 23 September 2015
Cited by 1 | PDF Full-text (618 KB) | HTML Full-text | XML Full-text
Abstract
Detection of low-abundance nucleic acids is a challenging task, which over the last two decades has been solved using enzymatic target amplification. Enzymatic synthesis enhances the signal so that diverse, scientifically and clinically relevant molecules can be identified and studied, including cancer [...] Read more.
Detection of low-abundance nucleic acids is a challenging task, which over the last two decades has been solved using enzymatic target amplification. Enzymatic synthesis enhances the signal so that diverse, scientifically and clinically relevant molecules can be identified and studied, including cancer DNA, viral nucleic acids, and regulatory RNAs. However, using enzymes increases the detection time and cost, not to mention the high risk of mistakes with amplification and data alignment. These limitations have stimulated a growing interest in enzyme-free methods within researchers and industry. In this review we discuss recent advances in signal-enhancing approaches aimed at nucleic acid diagnostics that do not require target amplification. Regardless of enzyme usage, signal enhancement is crucial for the reliable detection of nucleic acids at low concentrations. We pay special attention to novel nanomaterials, fluorescence microscopy, and technical advances in detectors for optical assessment. We summarize sensitivity parameters of the currently available assays and devices which makes this review relevant to the broad spectrum of researchers working in fields from biophysics, to engineering, to synthetic biology and bioorganic chemistry. Full article
(This article belongs to the Special Issue Feature Paper)

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Novel Signal-Enhancing Approaches for Optical Detection of Nucleic Acids – Going Beyond Amplification
Authors: Laura Miotke and Kira Astakhova
Affiliation: Nucleic Acid Center, Department of Physics, Chemistry & Pharmacy, University of Southern Denmark
Abstract: Currently applied nucleic acid detection is fully relied on enzymatic amplification of target sequences. This allows enhancing the signal for low-abundance nucleic acids which are the most biologically relevant. However, detection time and cost are increased when using enzymes, along with high risk of mistakes upon amplification and data alignment. This stimulates growing interest of researchers and industry to the enzyme-free methods.
Signal enhancing is crucial for the reliable enzyme-free detection of nucleic acids at low concentrations. In this focus review we discuss recent advances of signal-enhancing approaches aiming at enzyme-free nucleic acid diagnostics. A special attention is paid to nanomaterials and fluorescence microscopy. Sensitivity parameters of currently available detectors are also summarized in the review which makes it relevant to the broad community of researchers working within the fields of biophysics, engineering, synthetic biology and bioorganic chemistry.

Type of Paper: Article
Title: Steady-State Fluorescence and Lifetime Emission Study of pH-Sensitive Probes Based on I-Motif Forming Oligonucleotides Single and Double Labeled with Pyrene
Authors: Anna Dembska, Patrycja Rzepecka and Bernard Juskowiak
Affiliation: Faculty of Chemistry, A. Mickiewicz University, Umultowska 89b, 61-614 Poznan, Poland
Abstract: Cytosine-rich nucleic acids undergo pH-stimulated structural transitions leading to formation of an i-motif architecture at an acidic pH. Thus, i-motifs are good foundation for designing simple pH-sensitive fluorescent probes. We report here steady-state and time-resolved fluorescence studies of pyrene-labeled probes based on RET sequence: C4GC4GC4GC4TA (RET21), AC4GC4GC4GC4TA (RET21A) and C4GC4GC4GC4T (RET20). A comparative studies with single- and double-labeled i-motif probes were carried out. For each probe we have measured fluorescence spectra and decays for emission wavelength of 390 nm in the wide range of pH (from 4.0 to 8.0). Effect of the oligonucleotide sequence and the number of pyrene labels on the spectral characteristics of probes were discussed.

Title: Sol-gel-Based Materials for Optical Chemical Sensing
Author:
Dorota Wencel 1, Mariusz Barczak 2,* and Colette McDonagh 1
Affiliation: 1 Optical Sensors Laboratory, School of Physical Sciences, Biomedical Diagnostics Institute, Dublin City University, Dublin, 9 Ireland
2 Faculty of Chemistry, Maria Curie-Skłodowska University, 20-031 Lublin, Poland
Abstract: Silica sol-gel materials are widely used in the development of optical chemical sensors. They are usually exploited as porous support host matrices in which analyte-sensitive indicator dyes are entrapped. The versatility of the sol-gel process enables tailoring of the physical and chemical properties of the sensing matrix to meet the requirements of the desired application. This review will highlight the versatility and tailorability of sol-gel-based materials for use in a wide range of optical sensor applications. It will focus on the developments in sol-gel-based optical chemical sensors over the last 10 years. Recent novel developments in this area will be also emphasized and future trends will be discussed.

Title: ZnO Nanostructures: Fabrication and Gas Sensing Properties
Authors: Vardan Galstyana,b,*, Elisabetta Cominib,a, Andrea Ponzonia, Guido Fagliab,a, Giorgio Sberveglieria,b
Affiliation: aSensor Lab, CNR, National Institute of Optics (INO), Via Valotti 9, 25133 Brescia, Italy bSensor Lab, Department of Information Engineering, University of Brescia, Via Valotti 9, 25133 Brescia, Italy
Abstract: Chemical gas sensors have a wide variety of applications in environmental and safety monitoring that can be very useful to businesses and the general public. Environmentalists can use sensors to measure atmospheric pollution and monitor industrial emissions, and safety monitors can use sensors to detect harmful chemical vapors and explosives in public spaces, government and military facilities, and chemical processing plants. Detection of minor gas leaks, harmful chemical vapors and explosives in the environment has been a challenging research problem for many decades as it involves health, safety and environmental risks. Metal oxide chemical gas sensors have attracted considerable attention due to their obvious advantages, such as the low cost, production flexibility, chemical stability, rapid response and recovery time.
In this review, we will provide recent developments and reflects the impact of nanoscience into the fabrication and the gas sensing properties of ZnO based chemosensors.

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