Special Issue "Molecularly Imprinted Polymers—Robust Artificial Receptor Materials for Chemical Sensing"
A special issue of Chemosensors (ISSN 2227-9040).
Deadline for manuscript submissions: closed (30 November 2016)
Prof. Dr. Peter Lieberzeit
Molecularly imprinted polymers (MIP) have generated substantial interest in the sensor community for more than two decades now: MIP-based chemo- and biosensors today are a thriving field generating large numbers of innovations and applications. The reasons for this are:
- MIP are based on robust artificial matrices that are inherently long-term stable.
- MIP are highly selective materials that can compete with biological receptors.
- MIP are usually straightforward to synthesize.
- MIP are available as thin films, (nano)particles and bulk materials to name but a few.
Whereas the beginning of imprinting saw addressing many different templates, by now other questions have come to focus, such as applicability of the respective sensors in real-life conditions or compatibility of the MIP with production processes. This Special Issue of Chemosensors is dedicated to the technique and aims a demonstrating novel analytical applications of MIP, as well as novel synthesis techniques and innovative polymerization approaches. Work based on any transducer—be it optical, electrical, electrochemical or acoustic—and any polymer morphology—thin film, bulk, particulate—is welcome. Furthermore, high international visibility of your work will be granted both by collecting papers on one topic at one place and by open access publishing.
Prof. Dr. Peter Lieberzeit
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 350 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Molecular Imprinting
- Sensor Applications
- Chemical and Biological Analytes
- MIP Thin Films
- MIP Nanoparticles
- MIP composites
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Chemosensors Based on Molecularly Imprinted Acrylic Copolymers Prepared by Wet Phase Inversion
Authors: Ștefan-Ovidiu Dima et al.
Abstract: Three different acrylonitrile-acrylic acid (AN:AA) uncrosslinked copolymers were molecularly imprinted with diosgenin by wet phase inversion on the surface of three glassy carbon electrodes (GCE) in order to evaluate the detection performances of each molecularly imprinted polymer sensor (MIPS). Phase inversion, also known as alternative molecular imprinting method, consisted in this case in drop-casting a dimethylformamide solution of template (diosgenin) and polymer matrix (AN:AA copolymers) on the GCE surface, followed by the coagulation (phase inversion) of the MIP film on the GCE surface in the presence of water as non-solvent, reason for which the method is called “wet”, a dry phase inversion occurring in a gaseous environment. The last step of molecular imprinting method is represented by template extraction in order to generate the binding cavities with molecular recognition properties. Cyclic voltammetry and amperometry were employed to characterize the obtained MIPS in phosphate-buffered saline solution (PBS), at pH 7.4, using Ag/AgCl as reference electrode and Pt wire as counter electrode. It was observed that the p(AN:AA)/GCE MIPS were stable in the buffered electrolyte and that these new MIP-based chemosensors have good properties that recommend them for the detection of bioactive species like diosgenin.
Title: Gravimetric viral diagnostics: QCM based biosensors for early detection of viruses
Authors: Adnan Mujahid1, Adeel Afzal2,3*, Romana Schirhagl4, Sadia Z. Bajwa5, Usman Latif3, Naseer Iqbal2
Affiliation: 1 Institute of Chemistry, University of Punjab, Quaid-i-Azam Campus, Lahore, 54000, Pakistan.
2Department of Chemistry, College of Science, University of Hafr Al Batin, PO Box 1803, Hafr Al Batin, 31991, Saudi Arabia.
3Interdisciplinary Research Centre in Biomedical Materials, COMSATS Institute of Information Technology, 1.5 KM Defence Road, Off. Raiwind Road, Lahore, 54000, Pakistan.
4Groningen University, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, Netherlands.
5National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan.
Abstract: The viruses are pathogenic microorganisms that can inhabit and replicate in human bodies causing a number of widespread infectious diseases such as influenza, gastroenteritis, hepatitis, meningitis, pneumonia, acquired immune deficiency syndrome (AIDS) etc. A majority of these viral diseases are contagious and can spread from infected to healthy beings. The most important step in the treatment of these contagious diseases and to prevent their unwanted spread is to timely detect the disease-causing viruses. Gravimetric viral diagnostics based on quartz crystal microbalance (QCM) transducers and natural or synthetic receptors are miniaturized sensing platforms that can selectively recognize and quantify harmful virus species. Herein, a review of the label-free QCM virus sensors for clinical diagnostics and point of care (POC) applications is presented with major emphasis on the nature and performance of different receptors ranging from the natural or synthetic antibodies to selective macromolecular materials such as DNA and aptamers. A performance comparison of different receptors is provided and their limitations are discussed.
Keywords: Aptamer; epitope imprinting; imprinted polymer; natural antibodies; quartz crystal microbalance; virus sensor.