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Chemosensors 2016, 4(4), 22; doi:10.3390/chemosensors4040022

Development and Application of Electrochemical Sensor Based on Molecularly Imprinted Polymer and Carbon Nanotubes for the Determination of Carvedilol

1
Departamento de Ciências Naturais, Universidade Federal de São João del Rei (UFSJ), Campus Dom Bosco, Praça Dom Helvécio 74, Fábricas 36301-160, São João del Rei, MG, Brazil
2
Departamento de Química, Universidade Estadual de Londrina (UEL), Rod. Celso Garcia Cid, PR 445 Km 380, Campus Universitário, Londrina, PR, CEP 86051-990, Brazil
3
Instituto Nacional de Ciência e Tecnologia (INCT) de Bioanalítica, Universidade Estadual de Campinas (UNICAMP), Instituto de Química, Departamento de Química Analítica, Cidade Universitária Zeferino Vaz s/n, CEP 13083-970, Campinas, SP, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Peter Lieberzeit
Received: 5 August 2016 / Revised: 18 October 2016 / Accepted: 11 November 2016 / Published: 27 November 2016
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Abstract

This work describes the preparation of a glassy carbon electrode (GCE) modified with molecularly imprinted polymer (MIP) and multiwalled carbon nanotubes (MWCNTs) for determination of carvedilol (CAR). Electrochemical behavior of CAR on the modified electrode was evaluated using cyclic voltammetry. The best composition was found to be 65% (m/m) of MIP. Under optimized conditions (pH 8.5 in 0.25 mol L−1 Britton–Robinson buffer and 0.1 mol L−1 KCl) the voltammetric method showed a linear response for CAR in the range of 50–325 µmol L−1 (R = 0.9755), with detection and quantification limits of 16.14 µmol L−1 and 53.8 µmol L−1, respectively. The developed method was successfully applied for determination of CAR in real samples of pharmaceuticals. The sensor presented good sensitivity, rapid detection of CAR, and quick and easy preparation. Furthermore, the material used as modifier has a simple synthesis and its amount utilized is very small, thus illustrating the economic feasibility of this sensor. View Full-Text
Keywords: molecularly imprinted polymer; multi-walled carbon nanotubes; glassy carbon electrode; carvedilol; tablet sample molecularly imprinted polymer; multi-walled carbon nanotubes; glassy carbon electrode; carvedilol; tablet sample
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MDPI and ACS Style

Coelho, M.K.L.; Giarola, J.F.; da Silva, A.T.M.; Tarley, C.R.T.; Borges, K.B.; Pereira, A.C. Development and Application of Electrochemical Sensor Based on Molecularly Imprinted Polymer and Carbon Nanotubes for the Determination of Carvedilol. Chemosensors 2016, 4, 22.

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