Special Issue "Cell Death and Cancer"

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A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: closed (30 December 2010)

Special Issue Editor

Guest Editor
Prof. Dr. Afshin Samali
Director of Apoptosis Research Centre, School of Natural Sciences, National University of Ireland - Galway, University Road, Galway, Ireland
Website: http://www.nuigalway.ie/biochemistry/staff/samali/index.html
E-Mail: afshin.samali@nuigalway.ie
Phone: +353 91 492440
Fax: +353 91 494596
Interests: apoptosis; cell death; autophagy; TRAIL; heat shock proteins; Endoplasmic Reticulum stress; hypoxia

Special Issue Information

Dear Colleagues,

Cell death is involved in a variety of biological processes including morphogenesis, maintaining tissue homeostasis and elimination of harmful cells. Deregulation of proliferation, together with a reduction in cell death, is both necessary and sufficient for tumor development, progression, and resistance to therapy. The mechanisms of cell death and cell survival are complex and involve not only apoptosis and necrosis, but also their cross-talk with other programmed intracellular processes such as autophagy. In addition, the tumor microenvironment has a great impact on cell death, cell signaling, tumor metabolism, cell survival, and therapeutic responsiveness. The central focus of the special issue on “Cell Death and Cancer” is cell death regulation and how to exploit it for therapeutic gain. The main topics will include, but are not limited to, the role of cell death (e.g., apoptosis and necrosis) and cell survival pathways (e.g., autophagy) in tumorigenesis; targeting autophagy and cell death pathways for tumor eradication; death receptor and mitochondria-mediated apoptosis; stress-activated and survival-related protein kinases (e.g., p38, JNK, AKT, etc.) and their role in cell death; novel strategies to target anti-apoptotic proteins (SMAC mimetics, BH3 mimetics etc.).

Thank you for your collaboration.

Prof. Dr. Afshin Samali
Guest Editor

Keywords

  • apoptosis
  • autophagy
  • Bcl-2 family
  • caspases
  • cell death
  • cell survival
  • death receptors
  • mitochondria
  • oncogenes
  • tumor suppressor genes

Published Papers (25 papers)

Cancers 2012, 4(2), 442-474; doi:10.3390/cancers4020442
Received: 27 March 2012; in revised form: 28 March 2012 / Accepted: 10 April 2012 / Published: 25 April 2012
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Cancers 2011, 3(4), 3921-3956; doi:10.3390/cancers3043921
Received: 30 June 2011; in revised form: 26 September 2011 / Accepted: 10 October 2011 / Published: 21 October 2011
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Cancers 2011, 3(3), 2955-2974; doi:10.3390/cancers3032955
Received: 3 June 2011; in revised form: 7 July 2011 / Accepted: 14 July 2011 / Published: 19 July 2011
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Cancers 2011, 3(2), 2516-2539; doi:10.3390/cancers3022516
Received: 24 March 2011; in revised form: 26 April 2011 / Accepted: 3 May 2011 / Published: 3 June 2011
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Cancers 2011, 3(2), 2462-2477; doi:10.3390/cancers3022462
Received: 21 March 2011; in revised form: 27 April 2011 / Accepted: 11 May 2011 / Published: 20 May 2011
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Cancers 2011, 3(2), 1929-1946; doi:10.3390/cancers3021929
Received: 30 December 2010; in revised form: 21 March 2011 / Accepted: 6 April 2011 / Published: 11 April 2011
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Cancers 2011, 3(2), 1798-1820; doi:10.3390/cancers3021798
Received: 16 February 2011; in revised form: 11 March 2011 / Accepted: 11 March 2011 / Published: 1 April 2011
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Cancers 2011, 3(2), 1639-1671; doi:10.3390/cancers3021639
Received: 26 February 2011; in revised form: 15 March 2011 / Accepted: 16 March 2011 / Published: 29 March 2011
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Cancers 2011, 3(2), 1605-1621; doi:10.3390/cancers3021605
Received: 10 January 2011; in revised form: 18 February 2011 / Accepted: 7 March 2011 / Published: 29 March 2011
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Cancers 2011, 3(2), 1498-1512; doi:10.3390/cancers3021498
Received: 4 February 2011; in revised form: 16 March 2011 / Accepted: 17 March 2011 / Published: 24 March 2011
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Cancers 2011, 3(2), 1480-1497; doi:10.3390/cancers3021480
Received: 16 December 2010; in revised form: 27 January 2011 / Accepted: 30 January 2011 / Published: 24 March 2011
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Cancers 2011, 3(1), 1351-1371; doi:10.3390/cancers3011351
Received: 14 January 2011; in revised form: 28 February 2011 / Accepted: 3 March 2011 / Published: 15 March 2011
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Cancers 2011, 3(1), 1329-1350; doi:10.3390/cancers3011329
Received: 5 February 2011; in revised form: 15 February 2011 / Accepted: 10 March 2011 / Published: 15 March 2011
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Cancers 2011, 3(1), 1285-1310; doi:10.3390/cancers3011285
Received: 30 December 2010; in revised form: 22 February 2011 / Accepted: 9 March 2011 / Published: 11 March 2011
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Cancers 2011, 3(1), 1158-1181; doi:10.3390/cancers3011158
Received: 30 January 2011; Accepted: 23 February 2011 / Published: 7 March 2011
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Cancers 2011, 3(1), 1042-1080; doi:10.3390/cancers3011042
Received: 8 January 2011; in revised form: 18 February 2011 / Accepted: 1 March 2011 / Published: 3 March 2011
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Cancers 2011, 3(1), 994-1013; doi:10.3390/cancers3010994
Received: 7 December 2010; in revised form: 22 February 2011 / Accepted: 22 February 2011 / Published: 3 March 2011
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Cancers 2011, 3(1), 603-620; doi:10.3390/cancers3010603
Received: 29 December 2010; in revised form: 28 January 2011 / Accepted: 30 January 2011 / Published: 10 February 2011
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Cancers 2011, 3(1), 531-567; doi:10.3390/cancers3010531
Received: 23 December 2010; in revised form: 19 January 2011 / Accepted: 26 January 2011 / Published: 1 February 2011
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Cancers 2011, 3(1), 510-530; doi:10.3390/cancers3010510
Received: 7 December 2010; in revised form: 24 January 2011 / Accepted: 25 January 2011 / Published: 1 February 2011
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Cancers 2011, 3(1), 396-407; doi:10.3390/cancers3010396
Received: 3 December 2010; in revised form: 27 December 2010 / Accepted: 14 January 2011 / Published: 20 January 2011
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Cancers 2011, 3(1), 198-212; doi:10.3390/cancers3010198
Received: 30 November 2010; in revised form: 30 December 2010 / Accepted: 4 January 2011 / Published: 5 January 2011
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Cancers 2010, 2(4), 1952-1979; doi:10.3390/cancers2041952
Received: 8 November 2010; in revised form: 16 November 2010 / Accepted: 23 November 2010 / Published: 24 November 2010
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Cancers 2010, 2(3), 1717-1730; doi:10.3390/cancers2031717
Received: 23 August 2010; in revised form: 14 September 2010 / Accepted: 15 September 2010 / Published: 17 September 2010
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Cancers 2010, 2(3), 1555-1564; doi:10.3390/cancers2031555
Received: 23 June 2010; in revised form: 5 August 2010 / Accepted: 6 August 2010 / Published: 9 August 2010
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Last update: 25 February 2014

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