Deadline for manuscript submissions: closed (30 December 2010)
Special Issue Editor
Prof. Dr. Afshin Samali
Director of Apoptosis Research Centre, School of Natural Sciences, National University of Ireland - Galway, University Road, Galway, Ireland
Website: http://www.nuigalway.ie/biochemistry/staff/samali/index.html Fax: +353 91 494596 Interests: apoptosis; cell death; autophagy; TRAIL; heat shock proteins; Endoplasmic Reticulum stress; hypoxia
Special Issue Information
Cell death is involved in a variety of biological processes including morphogenesis, maintaining tissue homeostasis and elimination of harmful cells. Deregulation of proliferation, together with a reduction in cell death, is both necessary and sufficient for tumor development, progression, and resistance to therapy. The mechanisms of cell death and cell survival are complex and involve not only apoptosis and necrosis, but also their cross-talk with other programmed intracellular processes such as autophagy. In addition, the tumor microenvironment has a great impact on cell death, cell signaling, tumor metabolism, cell survival, and therapeutic responsiveness. The central focus of the special issue on “Cell Death and Cancer” is cell death regulation and how to exploit it for therapeutic gain. The main topics will include, but are not limited to, the role of cell death (e.g., apoptosis and necrosis) and cell survival pathways (e.g., autophagy) in tumorigenesis; targeting autophagy and cell death pathways for tumor eradication; death receptor and mitochondria-mediated apoptosis; stress-activated and survival-related protein kinases (e.g., p38, JNK, AKT, etc.) and their role in cell death; novel strategies to target anti-apoptotic proteins (SMAC mimetics, BH3 mimetics etc.).