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Protein Kinase C: An Attractive Target for Cancer Therapy
G. Gaslini Institute, L.go G. Gaslini 5, 16147, Genoa, Italy
Department of Experimental Medicine, General Pathology Section, University of Genoa, Via L.B. Alberti 2, 16132, Genoa, Italy
* Author to whom correspondence should be addressed.
Received: 23 December 2010; in revised form: 19 January 2011 / Accepted: 26 January 2011 / Published: 1 February 2011
Abstract: Apoptosis plays an important role during all stages of carcinogenesis and the development of chemoresistance in tumor cells may be due to their selective defects in the intracellular signaling proteins, central to apoptotic pathways. Consequently, many studies have focused on rendering the chemotherapy more effective in order to prevent chemoresistance and pre-clinical and clinical data has suggested that protein kinase C (PKC) may represent an attractive target for cancer therapy. Therefore, a complete understanding of how PKC regulates apoptosis and chemoresistance may lead to obtaining a PKC-based therapy that is able to reduce drug dosages and to prevent the development of chemoresistance.
Keywords: apoptosis; PKC; cancer; chemoresistance
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Marengo, B.; De Ciucis, C.; Ricciarelli, R.; Pronzato, M.A.; Marinari, U.M.; Domenicotti, C. Protein Kinase C: An Attractive Target for Cancer Therapy. Cancers 2011, 3, 531-567.
Marengo B, De Ciucis C, Ricciarelli R, Pronzato MA, Marinari UM, Domenicotti C. Protein Kinase C: An Attractive Target for Cancer Therapy. Cancers. 2011; 3(1):531-567.
Marengo, Barbara; De Ciucis, Chiara; Ricciarelli, Roberta; Pronzato, Maria A.; Marinari, Umberto M.; Domenicotti, Cinzia. 2011. "Protein Kinase C: An Attractive Target for Cancer Therapy." Cancers 3, no. 1: 531-567.