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Cancers 2011, 3(1), 1285-1310; doi:10.3390/cancers3011285
Review

Glutathione in Cancer Cell Death

1
, 2
 and 1,*
Received: 30 December 2010; in revised form: 22 February 2011 / Accepted: 9 March 2011 / Published: 11 March 2011
(This article belongs to the Special Issue Cell Death and Cancer)
View Full-Text   |   Download PDF [641 KB, uploaded 11 March 2011]
Abstract: Glutathione (L-γ-glutamyl-L-cysteinyl-glycine; GSH) in cancer cells is particularly relevant in the regulation of carcinogenic mechanisms; sensitivity against cytotoxic drugs, ionizing radiations, and some cytokines; DNA synthesis; and cell proliferation and death. The intracellular thiol redox state (controlled by GSH) is one of the endogenous effectors involved in regulating the mitochondrial permeability transition pore complex and, in consequence, thiol oxidation can be a causal factor in the mitochondrion-based mechanism that leads to cell death. Nevertheless GSH depletion is a common feature not only of apoptosis but also of other types of cell death. Indeed rates of GSH synthesis and fluxes regulate its levels in cellular compartments, and potentially influence switches among different mechanisms of death. How changes in gene expression, post-translational modifications of proteins, and signaling cascades are implicated will be discussed. Furthermore, this review will finally analyze whether GSH depletion may facilitate cancer cell death under in vivo conditions, and how this can be applied to cancer therapy.
Keywords: glutathione; cancer; cell death; apoptosis; necrosis; autophagy glutathione; cancer; cell death; apoptosis; necrosis; autophagy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ortega, A.L.; Mena, S.; Estrela, J.M. Glutathione in Cancer Cell Death. Cancers 2011, 3, 1285-1310.

AMA Style

Ortega AL, Mena S, Estrela JM. Glutathione in Cancer Cell Death. Cancers. 2011; 3(1):1285-1310.

Chicago/Turabian Style

Ortega, Angel L.; Mena, Salvador; Estrela, Jose M. 2011. "Glutathione in Cancer Cell Death." Cancers 3, no. 1: 1285-1310.



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