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Cancers 2011, 3(1), 1042-1080; doi:10.3390/cancers3011042

Cell-Centric View of Apoptosis and Apoptotic Cell Death-Inducing Antitumoral Strategies

Department of Cell Biology and Histology, School of Medicine and Dentistry, University of the Basque Country, 48940, Leioa (Bizkaia), Spain
Author to whom correspondence should be addressed.
Received: 8 January 2011 / Revised: 18 February 2011 / Accepted: 1 March 2011 / Published: 3 March 2011
(This article belongs to the Special Issue Cell Death and Cancer)
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Programmed cell death and especially apoptotic cell death, occurs under physiological conditions and is also desirable under pathological circumstances. However, the more we learn about cellular signaling cascades, the less plausible it becomes to find restricted and well-limited signaling pathways. In this context, an extensive description of pathway-connections is necessary in order to point out the main regulatory molecules as well as to select the most appropriate therapeutic targets. On the other hand, irregularities in programmed cell death pathways often lead to tumor development and cancer-related mortality is projected to continue increasing despite the effort to develop more active and selective antitumoral compounds. In fact, tumor cell plasticity represents a major challenge in chemotherapy and improvement on anticancer therapies seems to rely on appropriate drug combinations. An overview of the current status regarding apoptotic pathways as well as available chemotherapeutic compounds provides a new perspective of possible future anticancer strategies.
Keywords: apoptosis; classical-chemotherapy; targeted-chemotherapy apoptosis; classical-chemotherapy; targeted-chemotherapy

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Apraiz, A.; Boyano, M.D.; Asumendi, A. Cell-Centric View of Apoptosis and Apoptotic Cell Death-Inducing Antitumoral Strategies. Cancers 2011, 3, 1042-1080.

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