Cancers 2011, 3(1), 994-1013; doi:10.3390/cancers3010994
Review

Role of p53 in Cell Death and Human Cancers

1email and 2,* email
Received: 7 December 2010; in revised form: 22 February 2011 / Accepted: 22 February 2011 / Published: 3 March 2011
(This article belongs to the Special Issue Cell Death and Cancer)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: p53 is a nuclear transcription factor with a pro-apoptotic function. Since over 50% of human cancers carry loss of function mutations in p53 gene, p53 has been considered to be one of the classical type tumor suppressors. Mutant p53 acts as the dominant-negative inhibitor toward wild-type p53. Indeed, mutant p53 has an oncogenic potential. In some cases, malignant cancer cells bearing p53 mutations display a chemo-resistant phenotype. In response to a variety of cellular stresses such as DNA damage, p53 is induced to accumulate in cell nucleus to exert its pro-apoptotic function. Activated p53 promotes cell cycle arrest to allow DNA repair and/or apoptosis to prevent the propagation of cells with serious DNA damage through the transactivation of its target genes implicated in the induction of cell cycle arrest and/or apoptosis. Thus, the DNA-binding activity of p53 is tightly linked to its tumor suppressive function. In the present review article, we describe the regulatory mechanisms of p53 and also p53-mediated therapeutic strategies to cure malignant cancers.
Keywords: apoptosis; DNA damage; p53
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MDPI and ACS Style

Ozaki, T.; Nakagawara, A. Role of p53 in Cell Death and Human Cancers. Cancers 2011, 3, 994-1013.

AMA Style

Ozaki T, Nakagawara A. Role of p53 in Cell Death and Human Cancers. Cancers. 2011; 3(1):994-1013.

Chicago/Turabian Style

Ozaki, Toshinori; Nakagawara, Akira. 2011. "Role of p53 in Cell Death and Human Cancers." Cancers 3, no. 1: 994-1013.

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