Next Article in Journal
Vitamin D and Pancreatic Cancer—An Update
Next Article in Special Issue
Parathyroid Hormone-Related Protein (PTHrP): A Key Regulator of Life/Death Decisions by Tumor Cells with Potential Clinical Applications
Previous Article in Journal
Dependence of Relative Expression of NTR1 and EGFR on Cell Density and Extracellular pH in Human Pancreatic Cancer Cell Lines
Previous Article in Special Issue
The Enigmatic Roles of Caspases in Tumor Development
Cancers 2011, 3(1), 198-212; doi:10.3390/cancers3010198
Review

Nuclear Receptor Small Heterodimer Partner in Apoptosis Signaling and Liver Cancer

 and *
Received: 30 November 2010 / Revised: 30 December 2010 / Accepted: 4 January 2011 / Published: 5 January 2011
(This article belongs to the Special Issue Cell Death and Cancer)
View Full-Text   |   Download PDF [258 KB, uploaded 5 January 2011]   |   Browse Figures

Abstract

Small heterodimer partner (SHP, NR0B2) is a unique orphan nuclear receptor that contains the dimerization and a putative ligand-binding domain, but lacks the conserved DNA binding domain. SHP exerts its physiological function as an inhibitor of gene transcription through physical interaction with multiple nuclear receptors and transcriptional factors. SHP is a critical transcriptional regulator affecting diverse biological functions, including bile acid, cholesterol and lipid metabolism, glucose and energy homeostasis, and reproductive biology. Recently, we and others have demonstrated that SHP is an epigenetically regulated transcriptional repressor that suppresses the development of liver cancer. In this review, we summarize recent major findings regarding the role of SHP in cell proliferation, apoptosis, and DNA methylation, and discuss recent progress in understanding the function of SHP as a tumor suppressor in the development of liver cancer. Future study will be focused on identifying SHP associated novel pro-oncogenes and anti-oncogenes in liver cancer progression and applying the knowledge gained on SHP in liver cancer prevention, diagnosis and treatment.
Keywords: nuclear receptors; small heterodimer partner; apoptosis; cell cycle; liver cancer nuclear receptors; small heterodimer partner; apoptosis; cell cycle; liver cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Zhang, Y.; Wang, L. Nuclear Receptor Small Heterodimer Partner in Apoptosis Signaling and Liver Cancer. Cancers 2011, 3, 198-212.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert