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Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy
Cancers 2011, 3(2), 1798-1820; doi:10.3390/cancers3021798

Apoptosis and DNA Methylation

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Received: 16 February 2011 / Revised: 11 March 2011 / Accepted: 11 March 2011 / Published: 1 April 2011
(This article belongs to the Special Issue Cell Death and Cancer)
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Abstract: Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can activate apoptotic pathways associated with maintenance of genome integrity. This perspective focuses on the pathways linking DNA methyltransferases and methyl-CpG binding proteins to apoptosis, and includes new bioinformatic analyses to characterize the evolutionary origin of two G/T mismatch-specific thymine DNA glycosylases, MBD4 and TDG.
Keywords: epigenetics; Dnmt1; apoptosis; Mbd4; TDG; demethylation; 5-hydroxymethylation; DNA repair epigenetics; Dnmt1; apoptosis; Mbd4; TDG; demethylation; 5-hydroxymethylation; DNA repair
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Meng, H.X.; Hackett, J.A.; Nestor, C.; Dunican, D.S.; Madej, M.; Reddington, J.P.; Pennings, S.; Harrison, D.J.; Meehan, R.R. Apoptosis and DNA Methylation. Cancers 2011, 3, 1798-1820.

AMA Style

Meng HX, Hackett JA, Nestor C, Dunican DS, Madej M, Reddington JP, Pennings S, Harrison DJ, Meehan RR. Apoptosis and DNA Methylation. Cancers. 2011; 3(2):1798-1820.

Chicago/Turabian Style

Meng, Huan X.; Hackett, James A.; Nestor, Colm; Dunican, Donncha S.; Madej, Monika; Reddington, James P.; Pennings, Sari; Harrison, David J.; Meehan, Richard R. 2011. "Apoptosis and DNA Methylation." Cancers 3, no. 2: 1798-1820.

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