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Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy
Cancers 2011, 3(2), 1798-1820; doi:10.3390/cancers3021798

Apoptosis and DNA Methylation

1 MRC Human Genetics Unit, IGMM, Western General Hospital, Edinburgh EH4 2XU, UK 2 Breakthrough Research Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK 3 Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK
* Author to whom correspondence should be addressed.
Received: 16 February 2011 / Revised: 11 March 2011 / Accepted: 11 March 2011 / Published: 1 April 2011
(This article belongs to the Special Issue Cell Death and Cancer)
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Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can activate apoptotic pathways associated with maintenance of genome integrity. This perspective focuses on the pathways linking DNA methyltransferases and methyl-CpG binding proteins to apoptosis, and includes new bioinformatic analyses to characterize the evolutionary origin of two G/T mismatch-specific thymine DNA glycosylases, MBD4 and TDG.
Keywords: epigenetics; Dnmt1; apoptosis; Mbd4; TDG; demethylation; 5-hydroxymethylation; DNA repair epigenetics; Dnmt1; apoptosis; Mbd4; TDG; demethylation; 5-hydroxymethylation; DNA repair
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Meng, H.X.; Hackett, J.A.; Nestor, C.; Dunican, D.S.; Madej, M.; Reddington, J.P.; Pennings, S.; Harrison, D.J.; Meehan, R.R. Apoptosis and DNA Methylation. Cancers 2011, 3, 1798-1820.

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