Cancers 2011, 3(2), 1798-1820; doi:10.3390/cancers3021798
Review

Apoptosis and DNA Methylation

1 MRC Human Genetics Unit, IGMM, Western General Hospital, Edinburgh EH4 2XU, UK 2 Breakthrough Research Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK 3 Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK
* Author to whom correspondence should be addressed.
Received: 16 February 2011; in revised form: 11 March 2011 / Accepted: 11 March 2011 / Published: 1 April 2011
(This article belongs to the Special Issue Cell Death and Cancer)
PDF Full-text Download PDF Full-Text [793 KB, uploaded 1 April 2011 09:08 CEST]
Abstract: Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can activate apoptotic pathways associated with maintenance of genome integrity. This perspective focuses on the pathways linking DNA methyltransferases and methyl-CpG binding proteins to apoptosis, and includes new bioinformatic analyses to characterize the evolutionary origin of two G/T mismatch-specific thymine DNA glycosylases, MBD4 and TDG.
Keywords: epigenetics; Dnmt1; apoptosis; Mbd4; TDG; demethylation; 5-hydroxymethylation; DNA repair

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Meng, H.X.; Hackett, J.A.; Nestor, C.; Dunican, D.S.; Madej, M.; Reddington, J.P.; Pennings, S.; Harrison, D.J.; Meehan, R.R. Apoptosis and DNA Methylation. Cancers 2011, 3, 1798-1820.

AMA Style

Meng HX, Hackett JA, Nestor C, Dunican DS, Madej M, Reddington JP, Pennings S, Harrison DJ, Meehan RR. Apoptosis and DNA Methylation. Cancers. 2011; 3(2):1798-1820.

Chicago/Turabian Style

Meng, Huan X.; Hackett, James A.; Nestor, Colm; Dunican, Donncha S.; Madej, Monika; Reddington, James P.; Pennings, Sari; Harrison, David J.; Meehan, Richard R. 2011. "Apoptosis and DNA Methylation." Cancers 3, no. 2: 1798-1820.

Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert