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Apoptosis and DNA Methylation
MRC Human Genetics Unit, IGMM, Western General Hospital, Edinburgh EH4 2XU, UK
Breakthrough Research Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK
* Author to whom correspondence should be addressed.
Received: 16 February 2011; in revised form: 11 March 2011 / Accepted: 11 March 2011 / Published: 1 April 2011
Abstract: Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can activate apoptotic pathways associated with maintenance of genome integrity. This perspective focuses on the pathways linking DNA methyltransferases and methyl-CpG binding proteins to apoptosis, and includes new bioinformatic analyses to characterize the evolutionary origin of two G/T mismatch-specific thymine DNA glycosylases, MBD4 and TDG.
Keywords: epigenetics; Dnmt1; apoptosis; Mbd4; TDG; demethylation; 5-hydroxymethylation; DNA repair
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Cite This Article
MDPI and ACS Style
Meng, H.X.; Hackett, J.A.; Nestor, C.; Dunican, D.S.; Madej, M.; Reddington, J.P.; Pennings, S.; Harrison, D.J.; Meehan, R.R. Apoptosis and DNA Methylation. Cancers 2011, 3, 1798-1820.
Meng HX, Hackett JA, Nestor C, Dunican DS, Madej M, Reddington JP, Pennings S, Harrison DJ, Meehan RR. Apoptosis and DNA Methylation. Cancers. 2011; 3(2):1798-1820.
Meng, Huan X.; Hackett, James A.; Nestor, Colm; Dunican, Donncha S.; Madej, Monika; Reddington, James P.; Pennings, Sari; Harrison, David J.; Meehan, Richard R. 2011. "Apoptosis and DNA Methylation." Cancers 3, no. 2: 1798-1820.