Cancers 2011, 3(2), 1480-1497; doi:10.3390/cancers3021480
Review

Role of Methionine Adenosyltransferase Genes in Hepatocarcinogenesis

1email, 2email and 1,* email
Received: 16 December 2010; in revised form: 27 January 2011 / Accepted: 30 January 2011 / Published: 24 March 2011
(This article belongs to the Special Issue Cell Death and Cancer)
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Abstract: Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver. Detection of HCC can be difficult, as most of the patients who develop this tumor have no symptoms other than those related to their longstanding liver disease. There is an urgent need to understand the molecular mechanisms that are responsible for the development of this disease so that appropriate therapies can be designed. Methionine adenosyltransferase (MAT) is an essential enzyme required for the biosynthesis of S-adenosylmethionine (AdoMet), an important methyl donor in the cell. Alterations in the expression of MAT genes and a decline in AdoMet biosynthesis are known to be associated with liver injury, cirrhosis and HCC. This review focuses on the role of MAT genes in HCC development and the scope for therapeutic strategies using these genes.
Keywords: methionine adenosyltransferase (MAT); hepatocellular carcinoma (HCC); S-adenosylmethionine (AdoMet)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ramani, K.; Mato, J.M.; Lu, S.C. Role of Methionine Adenosyltransferase Genes in Hepatocarcinogenesis. Cancers 2011, 3, 1480-1497.

AMA Style

Ramani K, Mato JM, Lu SC. Role of Methionine Adenosyltransferase Genes in Hepatocarcinogenesis. Cancers. 2011; 3(2):1480-1497.

Chicago/Turabian Style

Ramani, Komal; Mato, José M.; Lu, Shelly C. 2011. "Role of Methionine Adenosyltransferase Genes in Hepatocarcinogenesis." Cancers 3, no. 2: 1480-1497.



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