Special Issue "Cancer Cell Invasion"


A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: closed (30 September 2014)

Special Issue Editor

Guest Editor
Dr. Scott A. Weed
Department of Neurobiology and Anatomy, Program in Cancer Cell Biology, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV, USA
Website: http://www.wvucancer.org/WeedLab/Home
E-Mail: scweed@hsc.wvu.edu
Interests: actin cytoskeletal regulation; kinase-based signal transduction; head and neck cancer progression; model systems of squamous cell carcinoma invasion; imaging of cervical lymph node metastasis; carcinogen-induced salivary gland abnormalities

Special Issue Information

Dear Colleagues,

For this issue, we are inviting experts to contribute original research reports and review articles that describe studies in the field of tumor cell invasion. As an essential step in the metastatic cascade, tumor invasion is required for regional and distant cancer cell dissemination. The switch from indolent to invasive neoplasia is complex and varied among different tumor types, but ultimately remains a major root cause underlying the degree of tumor aggressiveness and progression. The extent of invasion in any given cancer directly correlates with poor prognosis and outcomes, where the level of infiltrative involvement with normal tissues complicates patient treatment and management regimes. While different modes and molecular mechanisms have been identified that promote and maintain tumor invasiveness, much remains to be discovered and understood. This is underscored by the unintended promotion of tumor invasion with certain currently utilized targeted therapies, as well as the paucity of therapeutic interventions designed to directly target invasion.

Potential topics include, but are not limited to:

  • Mechanisms involved in breaching restrictive tissue barriers
  • Molecular process that drives tumor cell motility during invasion
  • Regulation of amoeboid and mesenchymal motility modes
  • EMT in tumor invasion
  • Therapeutic targeting of the invasive process
  • Mechanisms of intra- and extravasation

Dr. Scott A. Weed
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed Open Access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 800 CHF (Swiss Francs).


  • invasiveness
  • tumor invasion
  • invadopodia
  • collective invasion
  • ameboid motility
  • tumor intravasation
  • stroma proteolysis
  • EMT in invasion

Published Papers (1 paper)

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p. 2369-2386
by , , , ,  and
Cancers 2014, 6(4), 2369-2386; doi:10.3390/cancers6042369
Received: 29 September 2014; in revised form: 25 November 2014 / Accepted: 8 December 2014 / Published: 16 December 2014
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Last update: 7 April 2014

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