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Cancers 2015, 7(1), 266-286; doi:10.3390/cancers7010266

Desmoglein 3: A Help or a Hindrance in Cancer Progression?

1,2,†
and
1,†,*
1
Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Center for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Blizard Building, London E1 2AT, UK
2
Department of Cellular and Molecular Physiology, University of Liverpool, Institute of Translational Medicine, Liverpool L69 3BX, UK
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Scott A. Weed
Received: 26 November 2014 / Revised: 9 January 2015 / Accepted: 16 January 2015 / Published: 26 January 2015
(This article belongs to the Special Issue Cancer Cell Invasion)
View Full-Text   |   Download PDF [467 KB, uploaded 26 January 2015]

Abstract

Desmoglein 3 is one of seven desmosomal cadherins that mediate cell-cell adhesion in desmosomes. Desmosomes are the intercellular junctional complexes that anchor the intermediate filaments of adjacent cells and confer strong cell adhesion thus are essential in the maintenance of tissue architecture and structural integrity. Like adherens junctions, desmosomes function as tumour suppressors and are down regulated in the process of epithelial-mesenchymal transition and in tumour cell invasion and metastasis. However, recently several studies have shown that various desmosomal components, including desmoglein 3, are up-regulated in cancer with increased levels of expression correlating with the clinical stage of malignancy, implicating their potentiality to serve as a diagnostic and prognostic marker. Furthermore, in vitro studies have demonstrated that overexpression of desmoglein 3 in cancer cell lines activates several signal pathways that have an impact on cell morphology, adhesion and locomotion. These additional signalling roles of desmoglein 3 may not be associated to its adhesive function in desmosomes but rather function outside of the junctions, acting as a key regulator in the control of actin based cellular processes. This review will discuss recent advances which support the role of desmoglein 3 in cancer progression. View Full-Text
Keywords: desmoglein 3; cell signalling; desmosomes; cell-cell adhesion; squamous cell carcinoma; cancer biomarker; cancer progression; cancer suppression; metastasis desmoglein 3; cell signalling; desmosomes; cell-cell adhesion; squamous cell carcinoma; cancer biomarker; cancer progression; cancer suppression; metastasis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Brown, L.; Wan, H. Desmoglein 3: A Help or a Hindrance in Cancer Progression? Cancers 2015, 7, 266-286.

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