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Cancers 2015, 7(2), 585-597; doi:10.3390/cancers7020585

Profiling Invasiveness in Head and Neck Cancer: Recent Contributions of Genomic and Transcriptomic Approaches

1
Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland
2
Department of Clinical Research, Inselspital, Bern University Hospital, and University of Bern, MEM-E807, Murtenstrasse 35, Bern 3010, Switzerland
3
Department of Otorhinolaryngology—Head and Neck Surgery, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland
*
Authors to whom correspondence should be addressed.
Academic Editor: Scott A. Weed
Received: 17 January 2015 / Revised: 20 March 2015 / Accepted: 24 March 2015 / Published: 31 March 2015
(This article belongs to the Special Issue Cancer Cell Invasion)
View Full-Text   |   Download PDF [1030 KB, uploaded 31 March 2015]   |  

Abstract

High-throughput molecular profiling approaches have emerged as precious research tools in the field of head and neck translational oncology. Such approaches have identified and/or confirmed the role of several genes or pathways in the acquisition/maintenance of an invasive phenotype and the execution of cellular programs related to cell invasion. Recently published new-generation sequencing studies in head and neck squamous cell carcinoma (HNSCC) have unveiled prominent roles in carcinogenesis and cell invasion of mutations involving NOTCH1 and PI3K-patwhay components. Gene-expression profiling studies combined with systems biology approaches have allowed identifying and gaining further mechanistic understanding into pathways commonly enriched in invasive HNSCC. These pathways include antigen-presenting and leucocyte adhesion molecules, as well as genes involved in cell-extracellular matrix interactions. Here we review the major insights into invasiveness in head and neck cancer provided by high-throughput molecular profiling approaches. View Full-Text
Keywords: head and neck squamous cell carcinoma; cell invasion; whole exome sequencing; gene expression profiles; NOTCH 1; PI3K; epithelial-to-mesenchymal transition head and neck squamous cell carcinoma; cell invasion; whole exome sequencing; gene expression profiles; NOTCH 1; PI3K; epithelial-to-mesenchymal transition
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Nisa, L.; Aebersold, D.M.; Giger, R.; Caversaccio, M.D.; Borner, U.; Medová, M.; Zimmer, Y. Profiling Invasiveness in Head and Neck Cancer: Recent Contributions of Genomic and Transcriptomic Approaches. Cancers 2015, 7, 585-597.

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