Special Issue "Cancer and Glycosylation"
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: closed (31 March 2016)
Evidence has accumulated that carbohydrate-peptide epitopes do play a role in classical MHC-mediated immune responses. T-cell recognition of O-glycosylated peptides is potentially of high biomedical significance, because it can mediate the immune protection against microorganisms, and in particular the vaccination in anti-tumor therapies.
Research over three decades has revealed a series of tumor target antigens with proven potential in clinical diagnostics or in immunotherapeutic approaches. Among these are the Carcinoembryonic Antigen (CEA), the ovarian carcinoma marker CA125 (MUC16), and the epithelial tumor markers MUC1 and HER2neu. A common feature of the epithelial tumor markers is that they belong to the family of glycoproteins.
Tremendous progress has been made in recent years with respect to the mass spectrometric elucidation of site-specific glycosylation of proteins and to cancer-associated aspects of immunology, including the search for new markers in tumor diagnostics and the development of mucin glycopeptide-based cancer vaccines.
The purpose of this Special Issue is to convey the latest advances toward an understanding of the multiple roles N- and in particular O-glycosylation might play in epithelial cancers. Particular emphasis will be layed on mucin-linked epitopes in diagnostics and in the development of therapeutics, like those based on MUC1-glycopeptides in the context of active specific immunization.
We look forward to reading your contributions,
Prof. Dr. Franz-Georg Hanisch
Manuscript Submission Information
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- epithelial cancer
- inflammation and cancer progression
- breast cancer vaccines
- tumor evasion