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Special Issue "Functional Roles of Protein O-Glycosylation"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".

Deadline for manuscript submissions: 15 September 2018

Special Issue Editors

Guest Editor
Prof. Dr. Franz-Georg Hanisch

Institute of Biochemistry II, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 52, 50931 Köln, Germany
Website | E-Mail
Interests: mucin-type O-glycosylation; O-glycoproteins; mucins; MUC1; cancer; innate immunity; galactosemia; glycomics; (glyco)proteomics; mass spectrometry
Guest Editor
Dr. Isabelle Breloy

University of Applied Sciences Bonn-Rhein-Sieg, Department Natural Sciences, D-53359 Rheinbach, Germany
Website | E-Mail
Interests: glycoanalysis; O-mannosylation; O-glycans; LacdiNac; proteomics; glycomics

Special Issue Information

Dear Colleagues,

Complex glycosylation of proteins comprizing O- and N-linked glycan chains represents a high-impact topic in current biological research and, in particular, in human life sciences. In this Special Issue, we undertake the attempt to collect contributions that cover at least part of this huge and still-growing field by restriction to the functional roles of protein O-glycosylation. No focus on a particular subtype is envisaged, e.g., the abundant mucin-type forms (O-GalNAc) or the more rare types of O-glycosylation, such as O-Man, O-Fuc, or O-Glc. Mucin-type O-glycans on mucins or mucin-like glycoproteins express ABH and Lewis blood group antigens on epithelia with impact in cancer diagnosis or as entry targets in microbial infection. Functional aspects of other types of O-glycosylation were revealed in congenital disorders of glycosylation (dystro glycanopathies) and in epithelial cell adhesion mediated by E-cadherin (O-Man). In addition to the well established involvement of O-Fuc glycosylation in notch signaling, the terminal LacdiNAc modification of extracellular matrix glycoproteins might play roles in the regulatory control of stem cell renewal.  

Prof. Dr. Franz-Georg Hanisch
Dr. Isabelle Breloy
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • O-glycosylation
  • membrane organization
  • cellular trafficking
  • cell-cell binding
  • cell-matrix binding
  • innate immunity
  • immunology
  • cancer

Published Papers

This special issue is now open for submission.
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