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Biomolecules 2016, 6(2), 26; doi:10.3390/biom6020026

A Bitter Sweet Symphony: Immune Responses to Altered O-glycan Epitopes in Cancer

Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, 1081 HZ, The Netherlands
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Academic Editor: Franz-Georg Hanisch
Received: 30 March 2016 / Revised: 20 April 2016 / Accepted: 22 April 2016 / Published: 3 May 2016
(This article belongs to the Special Issue Cancer and Glycosylation)
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Abstract

The appearance of aberrant glycans on the tumor cell surface is one of the emerging hallmarks of cancer. Glycosylation is an important post-translation modification of proteins and lipids and is strongly affected by oncogenesis. Tumor-associated glycans have been extensively characterized regarding their composition and tumor-type specific expression patterns. Nevertheless whether and how tumor-associated glycans contribute to the observed immunomodulatory actions by tumors has not been extensively studied. Here, we provide a detailed overview of the current knowledge on how tumor-associated O-glycans affect the anti-tumor immune response, thereby focusing on truncated O-glycans present on epithelial tumors and mucins. These tumor-associated O-glycans and mucins bind a variety of lectin receptors on immune cells to facilitate the subsequently induction of tolerogenic immune responses. We, therefore, postulate that tumor-associated glycans not only support tumor growth, but also actively contribute to immune evasion. View Full-Text
Keywords: cancer; O-glycosylation; immunity; Siglec; C-type lectin cancer; O-glycosylation; immunity; Siglec; C-type lectin
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Cornelissen, L.A.; Van Vliet, S.J. A Bitter Sweet Symphony: Immune Responses to Altered O-glycan Epitopes in Cancer. Biomolecules 2016, 6, 26.

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