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Dry Distillation of Radioiodine from TeO2 Targets
Copenhagen University Hospital Herlev, Herlev Ringvej 75, DK-2730 Herlev, Denmark
* Author to whom correspondence should be addressed.
Received: 26 July 2013; in revised form: 8 October 2013 / Accepted: 21 October 2013 / Published: 28 October 2013
Abstract: As medical cyclotrons are becoming more abundant, 123I and 124I are getting more attention as alternatives to 131I for diagnostics of thyroid disease. Both 123I and 124I provide better diagnostics, deliver less dose to patients and both reduce the risk of thyroid stunning, facilitating subsequent therapy. Dry distillation of radioiodine from tellurium dioxide targets has become the standard approach to producing these radioiodines. Setting up such a production of radioiodine is associated with a lengthy optimization of the process and for this purpose natural tellurium is often used for economical reasons. In this paper, the distillation parameters are scrutinized to ensure optimal distillation temperature, in order to minimize time spent and prevent loss of expensive target material. It is further demonstrated how the individual iodine isotopes, produced from proton bombardment of natTe, will diffuse out of the target in a time dependent ratio. We believe the effect is due to the isotopes having their maximum cross section at different energies. The individual isotopes produced will thus have their highest concentration at different depths in the target. This results in individual mean diffusion lengths and diffusion times for the different isotopes.
Keywords: cyclotron; radioiodine; production; distillation; iodine-124; tellurium dioxide
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MDPI and ACS Style
Fonslet, J.; Koziorowski, J. Dry Distillation of Radioiodine from TeO2 Targets. Appl. Sci. 2013, 3, 675-683.
Fonslet J, Koziorowski J. Dry Distillation of Radioiodine from TeO2 Targets. Applied Sciences. 2013; 3(4):675-683.
Fonslet, Jesper; Koziorowski, Jacek. 2013. "Dry Distillation of Radioiodine from TeO2 Targets." Appl. Sci. 3, no. 4: 675-683.