Abstract: About 50% of the 1.4 GeV CERN (European Organization for Nuclear Research, www.cern.ch) protons are sent onto targets to produce radioactive beams by online mass separation at the Isotope Separator Online Device (ISOLDE) facility, for a wide range of studies in fundamental and applied physics. CERN-MEDICIS is a spin-off dedicated to R&D in life sciences and medical applications. It is located in an extension of the Class A building presently under construction. It will comprise laboratories to receive the irradiated targets from a new station located at the dump position behind the ISOLDE production targets. An increasing range of innovative isotopes will thus progressively become accessible from the start-up of the facility in 2015 onward; for fundamental studies in cancer research, for new imaging and therapy protocols in cell and animal models and for pre-clinical trials, possibly extended to specific early phase clinical studies up to Phase I trials. Five hundred megabecquerel isotope batches purified by electromagnetic mass separation combined with chemical methods will be collected on a weekly basis. A possible future upgrade with gigabecquerel pharmaceutical-grade i.e., current good manufacturing practices (cGMP) batch production capabilities is finally presented.
Keywords: CERN-MEDICIS; ISOLDE; CERN; radioisotope; radiolanthanides; bioconjugates; targeted radiotherapy; targeted alpha therapy (TAT); cancer; PET imaging; theranostics
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dos Santos Augusto, R.M.; Buehler, L.; Lawson, Z.; Marzari, S.; Stachura, M.; Stora, T.; CERN-MEDICIS collaboration. CERN-MEDICIS (Medical Isotopes Collected from ISOLDE): A New Facility. Appl. Sci. 2014, 4, 265-281.
dos Santos Augusto RM, Buehler L, Lawson Z, Marzari S, Stachura M, Stora T, CERN-MEDICIS collaboration. CERN-MEDICIS (Medical Isotopes Collected from ISOLDE): A New Facility. Applied Sciences. 2014; 4(2):265-281.
dos Santos Augusto, Ricardo M.; Buehler, Leo; Lawson, Zoe; Marzari, Stefano; Stachura, Monika; Stora, Thierry; CERN-MEDICIS collaboration. 2014. "CERN-MEDICIS (Medical Isotopes Collected from ISOLDE): A New Facility." Appl. Sci. 4, no. 2: 265-281.