Table of Contents
Genes, Volume 9, Issue 2 (February 2018)
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Cover Story (view full-size image) ADAR2, the main enzyme involved in the RNA editing process in the central nervous system, works as [...] Read more. ADAR2, the main enzyme involved in the RNA editing process in the central nervous system, works as a dimer and can be spliced into two splicing isoforms translated into two active proteins: ADAR2a and ADAR2b. They show different RNA editing efficiencies on many substrates, where ADAR2a is more active than ADAR2b. This feature is not linked to different homodimerization properties; it is more likely due to the interference to the RNA interaction of an extra ten amino acid loop in the ADAR2b structure.