Next Article in Journal
Characterization of the Symbiotic Nitrogen-Fixing Common Bean Low Phytic Acid (lpa1) Mutant Response to Water Stress
Next Article in Special Issue
Alternative Splicing of Transcription Factors Genes in Muscle Physiology and Pathology
Previous Article in Journal
Exploration and Exploitation of Novel SSR Markers for Candidate Transcription Factor Genes in Lilium Species
Previous Article in Special Issue
Characterization of TTN Novex Splicing Variants across Species and the Role of RBM20 in Novex-Specific Exon Splicing
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessReview
Genes 2018, 9(2), 98; https://doi.org/10.3390/genes9020098

Modulation of VEGF-A Alternative Splicing as a Novel Treatment in Chronic Kidney Disease

Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, EX1 2LU, UK
*
Authors to whom correspondence should be addressed.
Received: 2 December 2017 / Revised: 8 February 2018 / Accepted: 9 February 2018 / Published: 15 February 2018
(This article belongs to the Special Issue Aberrant Pre-mRNA Splicing in Disease)
View Full-Text   |   Download PDF [1010 KB, uploaded 22 February 2018]   |  

Abstract

Vascular endothelial growth factor A (VEGF-A) is a prominent pro-angiogenic and pro-permeability factor in the kidney. Alternative splicing of the terminal exon of VEGF-A through the use of an alternative 3′ splice site gives rise to a functionally different family of isoforms, termed VEGF-Axxxb, known to have anti-angiogenic and anti-permeability properties. Dysregulation of the VEGF-Axxx/VEGF-Axxxb isoform balance has recently been reported in several kidney pathologies, including diabetic nephropathy (DN) and Denys–Drash syndrome. Using mouse models of kidney disease where the VEGF-A isoform balance is disrupted, several reports have shown that VEGF-A165b treatment/over-expression in the kidney is therapeutically beneficial. Furthermore, inhibition of certain splice factor kinases involved in the regulation of VEGF-A terminal exon splicing has provided some mechanistic insight into how VEGF-A splicing could be regulated in the kidney. This review highlights the importance of further investigation into the novel area of VEGF-A splicing in chronic kidney disease pathogenesis and how future studies may allow for the development of splicing-modifying therapeutic drugs. View Full-Text
Keywords: VEGF-A; alternative splicing; kidney disease VEGF-A; alternative splicing; kidney disease
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Stevens, M.; Oltean, S. Modulation of VEGF-A Alternative Splicing as a Novel Treatment in Chronic Kidney Disease. Genes 2018, 9, 98.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top