Modeling the Role of Wnt Signaling in Human and Drosophila Stem Cells
AbstractThe discovery of induced pluripotent stem (iPS) cells, barely more than a decade ago, dramatically transformed the study of stem cells and introduced a completely new way to approach many human health concerns. Although advances have pushed the field forward, human application remains some years away, in part due to the need for an in-depth mechanistic understanding. The role of Wnts in stem cells predates the discovery of iPS cells with Wnts established as major pluripotency promoting factors. Most work to date has been done using mouse and tissue culture models and few attempts have been made in other model organisms, but the recent combination of clustered regularly interspaced short palindromic repeats (CRISPR) gene editing with iPS cell technology provides a perfect avenue for exploring iPS cells in model organisms. Drosophila is an ideal organism for such studies, but fly iPS cells have not yet been made. In this opinion article, we draw parallels between Wnt signaling in human and Drosophila stem cell systems, propose ways to obtain Drosophila iPS cells, and suggest ways to exploit the versatility of the Drosophila system for future stem cell studies. View Full-Text
Share & Cite This Article
Kaur, P.; Jin, H.J.; Lusk, J.B.; Tolwinski, N.S. Modeling the Role of Wnt Signaling in Human and Drosophila Stem Cells. Genes 2018, 9, 101.
Kaur P, Jin HJ, Lusk JB, Tolwinski NS. Modeling the Role of Wnt Signaling in Human and Drosophila Stem Cells. Genes. 2018; 9(2):101.Chicago/Turabian Style
Kaur, Prameet; Jin, Helen J.; Lusk, Jay B.; Tolwinski, Nicholas S. 2018. "Modeling the Role of Wnt Signaling in Human and Drosophila Stem Cells." Genes 9, no. 2: 101.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.