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Genes 2018, 9(2), 109; https://doi.org/10.3390/genes9020109

Wnt Signaling and Its Impact on Mitochondrial and Cell Cycle Dynamics in Pluripotent Stem Cells

1
Department of Cell and Developmental Biology; Vanderbilt University, Nashville, TN 37232, USA
2
Vanderbilt Center for Stem Cell Biology; Vanderbilt University, Nashville, TN 37232, USA
3
Vanderbilt Ingram Cancer Center; Vanderbilt University, Nashville, TN 37232, USA
*
Author to whom correspondence should be addressed.
Received: 19 December 2017 / Revised: 13 February 2018 / Accepted: 14 February 2018 / Published: 19 February 2018
(This article belongs to the Special Issue Wnt Signaling in Stem Cells)
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Abstract

The core transcriptional network regulating stem cell self-renewal and pluripotency remains an intense area of research. Increasing evidence indicates that modified regulation of basic cellular processes such as mitochondrial dynamics, apoptosis, and cell cycle are also essential for pluripotent stem cell identity and fate decisions. Here, we review evidence for Wnt regulation of pluripotency and self-renewal, and its connections to emerging features of pluripotent stem cells, including (1) increased mitochondrial fragmentation, (2) increased sensitivity to cell death, and (3) shortened cell cycle. We provide a general overview of the stem cell–specific mechanisms involved in the maintenance of these uncharacterized hallmarks of pluripotency and highlight potential links to the Wnt signaling pathway. Given the physiological importance of stem cells and their enormous potential for regenerative medicine, understanding fundamental mechanisms mediating the crosstalk between Wnt, organelle-dynamics, apoptosis, and cell cycle will be crucial to gain insight into the regulation of stemness. View Full-Text
Keywords: stem cells; pluripotency; mitochondria; cell cycle; apoptosis; Wnt stem cells; pluripotency; mitochondria; cell cycle; apoptosis; Wnt
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Rasmussen, M.L.; Ortolano, N.A.; Romero-Morales, A.I.; Gama, V. Wnt Signaling and Its Impact on Mitochondrial and Cell Cycle Dynamics in Pluripotent Stem Cells. Genes 2018, 9, 109.

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