Next Issue
Previous Issue

E-Mail Alert

Add your e-mail address to receive forthcoming issues of this journal:

Journal Browser

Journal Browser

Table of Contents

Molecules, Volume 6, Issue 3 (March 2001), Pages 142-286, Articles M193-M210

  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.
  • You may sign up for e-mail alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Readerexternal link to open them.
View options order results:
result details:
Displaying articles 1-29
Export citation of selected articles as:

Research

Jump to: Review, Other

Open AccessArticle 7-(1-Acetoxymethylidene)Benzonorbornadiene: A Versatile Reagent for the Synthesis of 7-Formyl and 7-Hydroxymethyl Benzonorbornadienes
Molecules 2001, 6(3), 194-202; doi:10.3390/60300194
Received: 30 November 2000 / Revised: 16 January 2001 / Accepted: 16 January 2001 / Published: 28 February 2001
Cited by 2 | PDF Full-text (55 KB) | HTML Full-text | XML Full-text
Abstract
7-(1-Acetoxymethylidene)benzonorbornadiene 3, prepared in one step by the addition of benzyne to 6-acetoxyfulvene 2, is hydrolysed in acid solution to form a 3:2-epimeric mixture of syn- and anti- 7-formylbenzonorbornadienes 4 and 5, respectively; the corresponding 7-hydroxymethylbenzonorbornadienes 6 and 9 were produced by [...] Read more.
7-(1-Acetoxymethylidene)benzonorbornadiene 3, prepared in one step by the addition of benzyne to 6-acetoxyfulvene 2, is hydrolysed in acid solution to form a 3:2-epimeric mixture of syn- and anti- 7-formylbenzonorbornadienes 4 and 5, respectively; the corresponding 7-hydroxymethylbenzonorbornadienes 6 and 9 were produced by reduction of the formyl isomers with sodium borohydride. Full article
Open AccessArticle Synthesis of 1-(2'-O-Methyl-ß-D-ribofuranosyl)-1H-imidazo[4,5-d]pyridazine-4,7(5H,6H)-dione: An Attractive Building Block for Antisense and Triple-helical Applications
Molecules 2001, 6(3), 203-207; doi:10.3390/60300203
Received: 12 October 2000 / Revised: 18 January 2001 / Accepted: 19 January 2001 / Published: 28 February 2001
Cited by 2 | PDF Full-text (29 KB) | HTML Full-text | XML Full-text
Abstract
Synthesis of the title compound,1-(2'-O-methyl-ß-D-ribofuranosyl)-1H-imidazo-[4,5-d]pyridazine-4,7(5H,6H)-dione (1), is reported. It was synthesized in four steps, starting from methyl 1-(ß-D-ribofuranosyl)imidazo-4,5-dicarboxylate (2). The 3',5'-hydroxyl groups of 2 was protected with a bis-silylating agent to form 3, which was then methylated to form the corresponding 2'-O-methyl [...] Read more.
Synthesis of the title compound,1-(2'-O-methyl-ß-D-ribofuranosyl)-1H-imidazo-[4,5-d]pyridazine-4,7(5H,6H)-dione (1), is reported. It was synthesized in four steps, starting from methyl 1-(ß-D-ribofuranosyl)imidazo-4,5-dicarboxylate (2). The 3',5'-hydroxyl groups of 2 was protected with a bis-silylating agent to form 3, which was then methylated to form the corresponding 2'-O-methyl derivative 5. The silyl deprotection of the latter (to form 6), followed by treatment with hydrazine afforded the target nucleoside 1. The reported nucleoside has potentially beneficial applications in biomedicine based on antisense and triple-helical nucleic acid technologies. Full article
Open AccessArticle Crystal and Molecular Structures of N-benzyl-C-(2-pyridyl) nitrone and its ZnBr2 Complex. A Study of Their Reactivity
Molecules 2001, 6(3), 208-220; doi:10.3390/60300208
Received: 18 January 2001 / Accepted: 22 January 2001 / Published: 28 February 2001
Cited by 12 | PDF Full-text (121 KB) | HTML Full-text | XML Full-text
Abstract The ZnBr2 complex of the title compound has been studied by both structural and theoretical methods. Similar reactivities have been observed for the nitrone alone and the complex in 1,3-dipolar cycloadditions and nucleophilic additions. Full article
Open AccessArticle Comparison of Association Constants of Cyclodextrins and Their tert-Butyl Derivatives With Halogenbenzoic Acids and Acridine Derivatives
Molecules 2001, 6(3), 221-229; doi:10.3390/60300221
Received: 23 October 2000 / Revised: 19 January 2001 / Accepted: 22 January 2001 / Published: 28 February 2001
Cited by 8 | PDF Full-text (127 KB) | HTML Full-text | XML Full-text
Abstract
Association constants of complexes of a new class of cyclodextrin alkyl derivatives - randomly susbstituted tert-butyl derivatives (TB-CDs) with complete set of mono-halobenzoic acids and acridine derivatives were measured using capillary electrophoresis and compared with association constants of natural cyclodextrins. In most [...] Read more.
Association constants of complexes of a new class of cyclodextrin alkyl derivatives - randomly susbstituted tert-butyl derivatives (TB-CDs) with complete set of mono-halobenzoic acids and acridine derivatives were measured using capillary electrophoresis and compared with association constants of natural cyclodextrins. In most cases the association constants of natural cyclodextrin and its corresponding tert-butyl derivative were comparable. Strong dependence of association constants on actual cyclodextrin concentration was observed for complexes of tert-butyl-α-cyclodextrin with acridine derivatives. Significant increase of the association constant occurred below the critical micelle concentration of the cyclodextrin derivative, while an increase above this value was less significant. Full article
Open AccessArticle Synthesis of Acridine-based DNA Bis-intercalating Agents
Molecules 2001, 6(3), 230-243; doi:10.3390/60300230
Received: 12 July 2000 / Revised: 30 August 2001 / Accepted: 18 January 2001 / Published: 28 February 2001
Cited by 18 | PDF Full-text (142 KB) | HTML Full-text | XML Full-text
Abstract
Methods for the synthesis of N1, N8-bis(9-acridinyl)-N4-(4-hydroxybenzyl)-spermidine and N1, N7-(hydroxybenzyl)-bis-(3-aminopropyl)amine were investigated. Thus monocyanoethylation of 4-methoxybenzylamine followed by treatment with 4-chlorobutyronitrile gave the dinitrile N-(2-cyanoethyl)-N-(3-cyanopropyl)-4-methoxybenzylamine. Subsequent in situ reduction with lithium aluminium [...] Read more.
Methods for the synthesis of N1, N8-bis(9-acridinyl)-N4-(4-hydroxybenzyl)-spermidine and N1, N7-(hydroxybenzyl)-bis-(3-aminopropyl)amine were investigated. Thus monocyanoethylation of 4-methoxybenzylamine followed by treatment with 4-chlorobutyronitrile gave the dinitrile N-(2-cyanoethyl)-N-(3-cyanopropyl)-4-methoxybenzylamine. Subsequent in situ reduction with lithium aluminium hydride gave the corresponding diamine. Biscyanoethylation of 4-methoxybenzylamine with 2 mole of acrylonitrile followed by reduction yielded the diamine N, N-bis-(3-aminopropyl)-4-methoxybenzylamine. Both diamines reacted smoothly with 9-methoxyacridine to give the bis-(9-acridinyl) compounds 11 and 15 but with 4,5-dimethyl-9-methoxyacridine, the bis compound 16 was produced in only low yields. Demethylation of the dinitriles by a variety of approaches all failed to give the corresponding hydroxybenzyl derivatives. These studies yielded useful methylated tyrosine derivatives which could also be iodinated. This study has been useful for elucidating chemical methods needed for the synthesis of the desired tyrosine-based bis acridine compound and for alerting us to the need to synthesise a more labile protected tyrosine intermediate which will be easily deprotected to afford the desired tyrosine-based bis acridine compound. Full article
Open AccessArticle Synthesis of (±)-trans-2,5-Diisopropylborolane
Molecules 2001, 6(3), 244-252; doi:10.3390/60300244
Received: 1 February 2001 / Accepted: 3 February 2001 / Published: 28 February 2001
PDF Full-text (44 KB) | HTML Full-text | XML Full-text
Abstract
The cyclic hydroboration of 2,7-dimethyl-2,6-octadiene (6) was studied. It was found that the stereochemical outcome of the reaction was dependent upon the solvent, temperature, time and the nature of the borane reagent. Pure racemic trans-2,5-diisopropylborolane (14) was isolated following selective complexation [...] Read more.
The cyclic hydroboration of 2,7-dimethyl-2,6-octadiene (6) was studied. It was found that the stereochemical outcome of the reaction was dependent upon the solvent, temperature, time and the nature of the borane reagent. Pure racemic trans-2,5-diisopropylborolane (14) was isolated following selective complexation of the cis-2,5-diisopropylborolane (15) with 1-(2-hydroxyethyl)-pyrrolidine. Full article
Open AccessArticle Preparation of Arylthiocyanates Using N,N′-Dibromo-N,N′-bis(2,5-dimethylbenzenesulphonyl) ethylenediamine and N,NDibromo-2,5-dimethylbenzenesulphonamide in the Presence of KSCN as a Novel Thiocyanating Reagent
Molecules 2001, 6(3), 253-257; doi:10.3390/60300253
Received: 3 December 2000 / Revised: 29 December 2000 / Accepted: 12 December 2000 / Published: 28 February 2001
Cited by 16 | PDF Full-text (66 KB) | HTML Full-text | XML Full-text
Abstract
N-Bromosulphonamides, synthesized via direct bromination of sulphonamides, react with several types of arene substrates in the presence of KSCN to afford aryl thiocyanates. The method appears to be generally applicable to benzenoid substrates with a wide range of substituents, such as [...] Read more.
N-Bromosulphonamides, synthesized via direct bromination of sulphonamides, react with several types of arene substrates in the presence of KSCN to afford aryl thiocyanates. The method appears to be generally applicable to benzenoid substrates with a wide range of substituents, such as N,N-dimethylaniline, p-xylene, anisole, mesitylene and cumene. Full article
Open AccessArticle Enantioselective Intramolecular CH-Insertions upon Cu-Catalyzed Decomposition of Phenyliodonium Ylides
Molecules 2001, 6(3), 258-266; doi:10.3390/60300258
Received: 24 January 2001 / Accepted: 7 February 2001 / Published: 28 February 2001
Cited by 13 | PDF Full-text (48 KB) | HTML Full-text | XML Full-text
Abstract
The Cu-catalyzed intramolecular CH insertion of phenyliodonium ylide 5b has been investigated at 0° C in the presence of several chiral ligands. Enantioselectivities vary in the range of 38–72 %, and are higher than those resulting from reaction of the diazo compound [...] Read more.
The Cu-catalyzed intramolecular CH insertion of phenyliodonium ylide 5b has been investigated at 0° C in the presence of several chiral ligands. Enantioselectivities vary in the range of 38–72 %, and are higher than those resulting from reaction of the diazo compound 5c at 65° C. The results are consistent with a carbenoid mechanism for Cu-catalyzed decomposition of phenyliodonium ylides. Full article
Open AccessArticle Aminoacids in the Synthesis of Heterocyclic Systems: The Synthesis of Triazinoquinazolinones, Triazepinoquinazolinones and Triazocinoquinazolinones of Potential Biological Interest
Molecules 2001, 6(3), 267-278; doi:10.3390/60300267
Received: 5 April 2000 / Revised: 29 August 2000 / Accepted: 1 February 2001 / Published: 28 February 2001
Cited by 16 | PDF Full-text (67 KB) | HTML Full-text | XML Full-text
Abstract A number of novel triazinoquinazolinones (5b,c and 8), triazepinoquinazolinones(5a, 6b, 7 and 9) and triazocinoquinazolinones (6a and 10) were obtained via nucleophilic interaction of 3-aminoquinazolinone derivatives 3 with different reagents. Full article
Open AccessArticle Intramolecular Acylation of Aryl- and Aroyl-Aliphatic Acids by the Action of Pyrophosphoryl Chloride and Phosphorus Oxychloride
Molecules 2001, 6(3), 279-286; doi:10.3390/60300279
Published: 31 March 2001
Cited by 12 | PDF Full-text (31 KB) | HTML Full-text | XML Full-text
Abstract
Both pyrophosphoryl chloride and phosphorus oxychloride react with aryl aliphatic acids to form mixed anhydrides which undergo intramolecular acylation to afford cyclic ketones without the addition of a Friedel-Crafts catalyst. Aryl and aroylbenzoic acids could be cyclized to the corresponding anthrones and [...] Read more.
Both pyrophosphoryl chloride and phosphorus oxychloride react with aryl aliphatic acids to form mixed anhydrides which undergo intramolecular acylation to afford cyclic ketones without the addition of a Friedel-Crafts catalyst. Aryl and aroylbenzoic acids could be cyclized to the corresponding anthrones and anthraquinones respectively. Full article

Review

Jump to: Research, Other

Open AccessReview Muscarinic Receptor Agonists and Antagonists
Molecules 2001, 6(3), 142-193; doi:10.3390/60300142
Received: 2 May 2000 / Revised: 16 January 2001 / Accepted: 16 January 2001 / Published: 28 February 2001
Cited by 28 | PDF Full-text (320 KB)
Abstract
A comprehensive review of pharmacological and medical aspects of the muscarinic class of acetylcholine agonists and antagonists is presented. The therapeutic benefits of achieving receptor subtype selectivity are outlined and applications in the treatment of Alzheimer’s disease are discussed. A selection of [...] Read more.
A comprehensive review of pharmacological and medical aspects of the muscarinic class of acetylcholine agonists and antagonists is presented. The therapeutic benefits of achieving receptor subtype selectivity are outlined and applications in the treatment of Alzheimer’s disease are discussed. A selection of chemical routes are described, which illustrate contemporary methodology for the synthesis of chiral medicinal compounds (asymmetric synthesis, chiral pool, enzymes). Routes to bicyclic intrannular amines and intramolecular Diels-Alder reactions are highlighted. Full article

Other

Jump to: Research, Review

Open AccessShort Note Bis(p-allylhimachalene)dichlorodipalladium
Molecules 2001, 6(3), M193; doi:10.3390/M193
Received: 11 December 2000 / Accepted: 15 December 2000 / Published: 25 March 2001
PDF Full-text (85 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note [5-Hydroxy-1-(2-morpholinoethyl)-1H-indol-3-yl](4-methoxyphenyl)methanone
Molecules 2001, 6(3), M194; doi:10.3390/M194
Received: 4 September 2000 / Accepted: 29 September 2000 / Published: 25 March 2001
PDF Full-text (92 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note 5-Isopropyl-N-(1H-1,2,3,4-tetrazol-5-yl)thiobenzo-2-oxazole Acetamide
Molecules 2001, 6(3), M195; doi:10.3390/M195
Received: 4 September 2000 / Accepted: 29 September 2000 / Published: 25 March 2001
PDF Full-text (92 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note N-(2-Ethylmorpholino)-3-bis-keto(1-naphthyl)oxindole
Molecules 2001, 6(3), M196; doi:10.3390/M196
Received: 4 September 2000 / Accepted: 29 September 2000 / Published: 25 March 2001
PDF Full-text (92 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note 1-(2-Ethylmorpholino)-5-benzyloxy-3-(1-napthoyl)pyrrolopyridine
Molecules 2001, 6(3), M197; doi:10.3390/M197
Received: 4 September 2000 / Accepted: 29 September 2000 / Published: 25 March 2001
PDF Full-text (91 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note N-(2-Ethylmorpholino)-3-bis-ketothiene
Molecules 2001, 6(3), M198; doi:10.3390/M198
Received: 4 September 2000 / Accepted: 29 September 2000 / Published: 25 March 2001
PDF Full-text (90 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note N-Benzyl-3-(2-morpholine)ethoxy-5-methoxy benzofuran-2-carboxamide
Molecules 2001, 6(3), M199; doi:10.3390/M199
Received: 4 September 2000 / Accepted: 29 September 2000 / Published: 25 March 2001
PDF Full-text (94 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note tert-Butyl methoxy(2-propynyl)carbamate
Molecules 2001, 6(3), M200; doi:10.3390/M200
Received: 8 December 2000 / Accepted: 15 December 2000 / Published: 25 March 2001
PDF Full-text (88 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note 1-(2-Vinyl-pyridin-3-yl)propanal O-methyloxime and 1-(6-Vinyl-pyridin-3-yl)propanal O-methyloxime
Molecules 2001, 6(3), M201; doi:10.3390/M201
Received: 8 December 2000 / Accepted: 15 December 2000 / Published: 25 March 2001
PDF Full-text (97 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Pyridine-3-carboxaldehyde O-methyloxime
Molecules 2001, 6(3), M202; doi:10.3390/M202
Received: 8 December 2000 / Accepted: 15 December 2000 / Published: 25 March 2001
PDF Full-text (89 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Methyl 3-Hydroxythieno[2,3-b]pyridine-2-carboxylate
Molecules 2001, 6(3), M203; doi:10.3390/M203
Received: 4 September 2000 / Accepted: 29 September 2000 / Published: 25 March 2001
Cited by 16 | PDF Full-text (89 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note 4,5-Dimethoxy-2-(4-methylbenzoyl)-1-(4-methylphenylsulfonylamido)benzene
Molecules 2001, 6(3), M204; doi:10.3390/M204
Received: 19 November 2000 / Accepted: 15 December 2000 / Published: 25 March 2001
PDF Full-text (89 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note 4-Hydroxy-methylen-4'-methyl-2,2'-bipyridine
Molecules 2001, 6(3), M205; doi:10.3390/M205
Received: 16 November 2000 / Accepted: 15 December 2000 / Published: 25 March 2001
PDF Full-text (15 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note 1-(Pyridin-3-yl)but-2-yn-1,4-diol
Molecules 2001, 6(3), M206; doi:10.3390/M206
Received: 8 December 2000 / Accepted: 15 December 2000 / Published: 25 March 2001
PDF Full-text (86 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note 1-(Pyridin-3-yl)-4-(triethylsilyloxy)-2-butyn-1-ol
Molecules 2001, 6(3), M207; doi:10.3390/M207
Received: 8 December 2000 / Accepted: 15 December 2000 / Published: 25 March 2001
PDF Full-text (87 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note 2-Methyl-5-chloromethyl-8-hydroxyquinoline
Molecules 2001, 6(3), M208; doi:10.3390/M208
Received: 9 November 2000 / Accepted: 15 December 2000 / Published: 25 March 2001
PDF Full-text (86 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Dibutyldichloro(1,10-phenanthroline-N1,N10)tin
Molecules 2001, 6(3), M209; doi:10.3390/M209
Received: 5 May 2000 / Accepted: 21 February 2001 / Published: 25 March 2001
PDF Full-text (89 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note (2,2'-Bipyridine-N,N')dibutyldiisothiocyanotin
Molecules 2001, 6(3), M210; doi:10.3390/M210
Received: 5 May 2000 / Accepted: 21 February 2001 / Published: 25 March 2001
PDF Full-text (89 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

Journal Contact

MDPI AG
Molecules Editorial Office
St. Alban-Anlage 66, 4052 Basel, Switzerland
molecules@mdpi.com
Tel. +41 61 683 77 34
Fax: +41 61 302 89 18
Editorial Board
Contact Details Submit to Molecules
Back to Top