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Molecules 2001, 6(3), 279-286; doi:10.3390/60300279
Article

Intramolecular Acylation of Aryl- and Aroyl-Aliphatic Acids by the Action of Pyrophosphoryl Chloride and Phosphorus Oxychloride

*  and
Department of Chemistry, Birzeit University, Birzeit, PO Box 14, Palestine- Via Israel
* Author to whom correspondence should be addressed.
Published: 31 March 2001
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Abstract

Both pyrophosphoryl chloride and phosphorus oxychloride react with aryl aliphatic acids to form mixed anhydrides which undergo intramolecular acylation to afford cyclic ketones without the addition of a Friedel-Crafts catalyst. Aryl and aroylbenzoic acids could be cyclized to the corresponding anthrones and anthraquinones respectively.
Keywords: Pyrophosphoryl chloride; Phosphorus oxychloride; Cyclodehydration; Cyclic ketones; Anthraquinones Pyrophosphoryl chloride; Phosphorus oxychloride; Cyclodehydration; Cyclic ketones; Anthraquinones
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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El-Sayrafi, S.; Rayyan, S. Intramolecular Acylation of Aryl- and Aroyl-Aliphatic Acids by the Action of Pyrophosphoryl Chloride and Phosphorus Oxychloride. Molecules 2001, 6, 279-286.

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