Intramolecular Acylation of Aryl- and Aroyl-Aliphatic Acids by the Action of Pyrophosphoryl Chloride and Phosphorus Oxychloride

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Molecules 2001, 6(3), 279-286; doi:10.3390/60300279

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Intramolecular Acylation of Aryl- and Aroyl-Aliphatic Acids by the Action of Pyrophosphoryl Chloride and Phosphorus Oxychloride

Sami El-Sayrafi* and Saleh Rayyan

Department of Chemistry, Birzeit University, Birzeit, PO Box 14, Palestine- Via Israel

* Author to whom correspondence should be addressed.

Published: 31 March 2001

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Abstract: Both pyrophosphoryl chloride and phosphorus oxychloride react with aryl aliphatic acids to form mixed anhydrides which undergo intramolecular acylation to afford cyclic ketones without the addition of a Friedel-Crafts catalyst. Aryl and aroylbenzoic acids could be cyclized to the corresponding anthrones and anthraquinones respectively.

Keywords: Pyrophosphoryl chloride; Phosphorus oxychloride; Cyclodehydration; Cyclic ketones; Anthraquinones

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MDPI and ACS Style

El-Sayrafi, S.; Rayyan, S. Intramolecular Acylation of Aryl- and Aroyl-Aliphatic Acids by the Action of Pyrophosphoryl Chloride and Phosphorus Oxychloride. Molecules 2001, 6, 279-286.

AMA Style

El-Sayrafi S, Rayyan S. Intramolecular Acylation of Aryl- and Aroyl-Aliphatic Acids by the Action of Pyrophosphoryl Chloride and Phosphorus Oxychloride. Molecules. 2001; 6(3):279-286.

Chicago/Turabian Style

El-Sayrafi, Sami; Rayyan, Saleh. 2001. "Intramolecular Acylation of Aryl- and Aroyl-Aliphatic Acids by the Action of Pyrophosphoryl Chloride and Phosphorus Oxychloride." Molecules 6, no. 3: 279-286.

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