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Molecules 2001, 6(3), 221-229; doi:10.3390/60300221

Comparison of Association Constants of Cyclodextrins and Their tert-Butyl Derivatives With Halogenbenzoic Acids and Acridine Derivatives

1
Department of Analytical Chemistry, Charles University, Albertov 2030, CZ-128 43 Prague 2, Czech Republic
2
Department of Organic Chemistry, Charles University, Albertov 2030, CZ-128 43 Prague 2, Czech Republic
3
Institute of Macromolecular Chemistry AS CR, Heyrovskeho nam. 2, CZ-162 06 Prague 6, Czech Republic
*
Author to whom correspondence should be addressed.
Received: 23 October 2000 / Revised: 19 January 2001 / Accepted: 22 January 2001 / Published: 28 February 2001
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Abstract

Association constants of complexes of a new class of cyclodextrin alkyl derivatives - randomly susbstituted tert-butyl derivatives (TB-CDs) with complete set of mono-halobenzoic acids and acridine derivatives were measured using capillary electrophoresis and compared with association constants of natural cyclodextrins. In most cases the association constants of natural cyclodextrin and its corresponding tert-butyl derivative were comparable. Strong dependence of association constants on actual cyclodextrin concentration was observed for complexes of tert-butyl-α-cyclodextrin with acridine derivatives. Significant increase of the association constant occurred below the critical micelle concentration of the cyclodextrin derivative, while an increase above this value was less significant.
Keywords: association constant; cyclodextrins; tert-butyl-cyclodextrins; capillary electrophoresis; benzoic acids; acridines; cricital micelle concentration association constant; cyclodextrins; tert-butyl-cyclodextrins; capillary electrophoresis; benzoic acids; acridines; cricital micelle concentration
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Pumera, M.; Matalová, R.; Jelínek, I.; Jindřich, J.; Jůza, J. Comparison of Association Constants of Cyclodextrins and Their tert-Butyl Derivatives With Halogenbenzoic Acids and Acridine Derivatives. Molecules 2001, 6, 221-229.

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