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Molecules 2001, 6(3), 142-193; doi:10.3390/60300142

Muscarinic Receptor Agonists and Antagonists

1
Division of Pharmacology, Welsh School of Pharmacy, Cardiff University, Cathays Park, Cardiff, CF10 3TB, UK
2
Department of Chemistry, Cardiff University, Cathays Park, Cardiff, CF10 3TB, UK
*
Author to whom correspondence should be addressed.
Received: 2 May 2000 / Revised: 16 January 2001 / Accepted: 16 January 2001 / Published: 28 February 2001
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Abstract

A comprehensive review of pharmacological and medical aspects of the muscarinic class of acetylcholine agonists and antagonists is presented. The therapeutic benefits of achieving receptor subtype selectivity are outlined and applications in the treatment of Alzheimer’s disease are discussed. A selection of chemical routes are described, which illustrate contemporary methodology for the synthesis of chiral medicinal compounds (asymmetric synthesis, chiral pool, enzymes). Routes to bicyclic intrannular amines and intramolecular Diels-Alder reactions are highlighted.
Keywords: Alzheimer’s disease; nicotine; acetylcholine; arecoline; himbacine; tacrine; cyclostelletamines; intramolecular Diels-Alder reaction; indole alkaloids Alzheimer’s disease; nicotine; acetylcholine; arecoline; himbacine; tacrine; cyclostelletamines; intramolecular Diels-Alder reaction; indole alkaloids
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Broadley, K.J.; Kelly, D.R. Muscarinic Receptor Agonists and Antagonists. Molecules 2001, 6, 142-193.

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