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Muscarinic Receptor Agonists and Antagonists
Division of Pharmacology, Welsh School of Pharmacy, Cardiff University, Cathays Park, Cardiff, CF10 3TB, UK
Department of Chemistry, Cardiff University, Cathays Park, Cardiff, CF10 3TB, UK
* Author to whom correspondence should be addressed.
Received: 2 May 2000; in revised form: 16 January 2001 / Accepted: 16 January 2001 / Published: 28 February 2001
Abstract: A comprehensive review of pharmacological and medical aspects of the muscarinic class of acetylcholine agonists and antagonists is presented. The therapeutic benefits of achieving receptor subtype selectivity are outlined and applications in the treatment of Alzheimer’s disease are discussed. A selection of chemical routes are described, which illustrate contemporary methodology for the synthesis of chiral medicinal compounds (asymmetric synthesis, chiral pool, enzymes). Routes to bicyclic intrannular amines and intramolecular Diels-Alder reactions are highlighted.
Keywords: Alzheimer’s disease; nicotine; acetylcholine; arecoline; himbacine; tacrine; cyclostelletamines; intramolecular Diels-Alder reaction; indole alkaloids
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MDPI and ACS Style
Broadley, K.J.; Kelly, D.R. Muscarinic Receptor Agonists and Antagonists. Molecules 2001, 6, 142-193.
Broadley KJ, Kelly DR. Muscarinic Receptor Agonists and Antagonists. Molecules. 2001; 6(3):142-193.
Broadley, Kenneth J.; Kelly, David R. 2001. "Muscarinic Receptor Agonists and Antagonists." Molecules 6, no. 3: 142-193.