Muscarinic Receptor Agonists and Antagonists
AbstractA comprehensive review of pharmacological and medical aspects of the muscarinic class of acetylcholine agonists and antagonists is presented. The therapeutic benefits of achieving receptor subtype selectivity are outlined and applications in the treatment of Alzheimer’s disease are discussed. A selection of chemical routes are described, which illustrate contemporary methodology for the synthesis of chiral medicinal compounds (asymmetric synthesis, chiral pool, enzymes). Routes to bicyclic intrannular amines and intramolecular Diels-Alder reactions are highlighted.
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Broadley, K.J.; Kelly, D.R. Muscarinic Receptor Agonists and Antagonists. Molecules 2001, 6, 142-193.
Broadley KJ, Kelly DR. Muscarinic Receptor Agonists and Antagonists. Molecules. 2001; 6(3):142-193.Chicago/Turabian Style
Broadley, Kenneth J.; Kelly, David R. 2001. "Muscarinic Receptor Agonists and Antagonists." Molecules 6, no. 3: 142-193.