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Molecules 2001, 6(3), 142-193; doi:10.3390/60300142
Review

Muscarinic Receptor Agonists and Antagonists

1 and 2,*
Received: 2 May 2000 / Revised: 16 January 2001 / Accepted: 16 January 2001 / Published: 28 February 2001
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Abstract

A comprehensive review of pharmacological and medical aspects of the muscarinic class of acetylcholine agonists and antagonists is presented. The therapeutic benefits of achieving receptor subtype selectivity are outlined and applications in the treatment of Alzheimer’s disease are discussed. A selection of chemical routes are described, which illustrate contemporary methodology for the synthesis of chiral medicinal compounds (asymmetric synthesis, chiral pool, enzymes). Routes to bicyclic intrannular amines and intramolecular Diels-Alder reactions are highlighted.
Keywords: Alzheimer’s disease; nicotine; acetylcholine; arecoline; himbacine; tacrine; cyclostelletamines; intramolecular Diels-Alder reaction; indole alkaloids Alzheimer’s disease; nicotine; acetylcholine; arecoline; himbacine; tacrine; cyclostelletamines; intramolecular Diels-Alder reaction; indole alkaloids
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Broadley, K.J.; Kelly, D.R. Muscarinic Receptor Agonists and Antagonists. Molecules 2001, 6, 142-193.

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